Lorenc Z Paul, Öhrlund Åke, Edsman Katarina
J Drugs Dermatol. 2017 Sep 1;16(9):876-882.
With the number of available dermal fillers increasing, so is the demand for scientifically based comparisons, often with rheological properties in focus. Since analytical results are always influenced by instrument settings, consensus on settings is essential to make comparison of results from different investigators more useful.
Preferred measurement settings for rheological analysis of hyaluronic acid (HA) fillers are suggested, and the reasoning behind the choices is presented by demonstrating the effect of different measurement settings on select commercial HA fillers.
Rheological properties of 8 HA fillers were measured in a frequency sweep from 10 to 0.01 Hz at 0.1% strain, using an Anton Paar MCR 301, a PP-25 measuring system with a gap of 1 mm at 25°C. A 30-min period was used for relaxation of the sample between loading and measuring.
The data presented here, together with previously published data, demonstrate differences in G' from 1.6 to 7.4 times for the same product.
A large part of the differences were concluded to be due to differences in rheometry measurement settings. The confusion from the many parameters involved in rheometry can be avoided by simply using the elastic modulus (G') to differentiate products.
J Drugs Dermatol. 2017;16(9):876-882.
.随着可用的真皮填充剂数量不断增加，对基于科学的比较的需求也在增加，这种比较通常聚焦于流变学特性。由于分析结果总是受到仪器设置的影响，因此就设置达成共识对于使不同研究者的结果比较更具实用性至关重要。
提出用于透明质酸（HA）填充剂流变学分析的首选测量设置，并通过展示不同测量设置对选定商业HA填充剂的影响来阐述选择背后的理由。
使用安东帕MCR 301型流变仪、PP - 25测量系统（间隙为1毫米），在25°C下以0.1%应变在10至0.01赫兹的频率扫描范围内测量8种HA填充剂的流变学特性。在加载和测量之间使用30分钟使样品松弛。
此处呈现的数据以及先前发表的数据表明，同一产品的储能模量（G'）相差1.6至7.4倍。
得出很大一部分差异是由于流变测量设置不同所致的结论。通过简单地使用弹性模量（G'）来区分产品，可以避免流变学中众多参数带来的混淆。
《药物皮肤病学杂志》。2017年；16(9):876 - 882。
