他克莫司与唑类药物联合抗皮炎外瓶霉的协同作用。
Synergistic Effects of Tacrolimus and Azoles against Exophiala dermatitidis.
机构信息
Department of Dermatology, Zhongshan Hospital Fudan University, Shanghai, China
The Second Clinical Medical College, Yangtze University, Jingzhou, China
出版信息
Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.00948-17. Print 2017 Dec.
Abstract
interactions of tacrolimus, a calcineurin inhibitor, and azoles, including itraconazole, voriconazole, and posaconazole, against planktonic cells and biofilms of were assessed via a broth microdilution checkerboard technique. A total of 16 clinical isolates were studied. The results revealed favorable synergistic inhibitory activity between tacrolimus and itraconazole, voriconazole, or posaconazole against 68.8%, 87.5%, and 100% of tested strains of planktonic , respectively.However, limited synergism was observed against biofilms of No antagonism was observed in all combinations.
摘要
采用肉汤微量棋盘稀释法评估了钙调神经磷酸酶抑制剂他克莫司与唑类药物（包括伊曲康唑、伏立康唑和泊沙康唑）对浮游细胞和生物膜的相互作用。共研究了 16 株临床分离株。结果表明，他克莫司与伊曲康唑、伏立康唑或泊沙康唑对浮游状态的分别有 68.8%、87.5%和 100%的受试菌株具有良好的协同抑制活性。然而，对生物膜的协同作用有限。在所有组合中均未观察到拮抗作用。
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