疑似非结核感染加重的中华支气管综合征患者。
Sinobronchial Syndrome Patients with Suspected Non-Tuberculous Infection Exacerbated by Infection.
作者信息
Watanabe Yuji, Sano Hirohito, Konno Shuichi, Kamioka Yasuhiro, Hariu Maya, Takano Kazuki, Yamada Mitsuhiro, Seki Masafumi
机构信息
Division of Infectious Diseases and Infection Control, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai City, Miyagi, Japan.
Laboratory for Clinical Microbiology, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Miyagi, Japan.
出版信息
Infect Drug Resist. 2022 Mar 20;15:1135-1141. doi: 10.2147/IDR.S359646. eCollection 2022.
BACKGROUND
is an environmental black fungus that rarely causes respiratory infections, yet its pathophysiological features and treatment regimens have not been established.
CASE SERIES
Two cases of exacerbations of chronic bronchitis and sinusitis due to infection in Japan are presented. Both patients were women, and non-tuberculous (NTM) infection was suspected based on chest radiological findings, but was detected from bronchial lavage fluid and nasal mucus, respectively. Both cases were successfully treated by antifungal agents such as liposomal amphotericin B, voriconazole, and itraconazole, but clarithromycin, rifampicin, ethambutol, and sitafloxacin for NTM were not effective.
CONCLUSION
can become a respiratory pathogen, especially in patients with chronic sinobronchial syndrome.
背景
是一种环境性黑真菌，很少引起呼吸道感染，但其病理生理特征和治疗方案尚未确定。
病例系列
介绍了日本两例因感染导致慢性支气管炎和鼻窦炎加重的病例。两名患者均为女性，根据胸部影像学检查结果怀疑为非结核分枝杆菌（NTM）感染，但分别从支气管灌洗液和鼻黏液中检测到。两例均通过脂质体两性霉素B、伏立康唑和伊曲康唑等抗真菌药物成功治疗，但用于NTM的克拉霉素、利福平、乙胺丁醇和西他沙星无效。
结论
可成为呼吸道病原体，尤其是在慢性鼻窦支气管综合征患者中。
需注意，原文中部分关键信息缺失，如具体的真菌名称未完整给出，可能会影响译文的准确性和流畅性。
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