• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

疑似非结核感染加重的中华支气管综合征患者。

Sinobronchial Syndrome Patients with Suspected Non-Tuberculous Infection Exacerbated by Infection.

作者信息

Watanabe Yuji, Sano Hirohito, Konno Shuichi, Kamioka Yasuhiro, Hariu Maya, Takano Kazuki, Yamada Mitsuhiro, Seki Masafumi

机构信息

Division of Infectious Diseases and Infection Control, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai City, Miyagi, Japan.

Laboratory for Clinical Microbiology, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Miyagi, Japan.

出版信息

Infect Drug Resist. 2022 Mar 20;15:1135-1141. doi: 10.2147/IDR.S359646. eCollection 2022.

DOI:10.2147/IDR.S359646
PMID:35340672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8948093/
Abstract

BACKGROUND

is an environmental black fungus that rarely causes respiratory infections, yet its pathophysiological features and treatment regimens have not been established.

CASE SERIES

Two cases of exacerbations of chronic bronchitis and sinusitis due to infection in Japan are presented. Both patients were women, and non-tuberculous (NTM) infection was suspected based on chest radiological findings, but was detected from bronchial lavage fluid and nasal mucus, respectively. Both cases were successfully treated by antifungal agents such as liposomal amphotericin B, voriconazole, and itraconazole, but clarithromycin, rifampicin, ethambutol, and sitafloxacin for NTM were not effective.

CONCLUSION

can become a respiratory pathogen, especially in patients with chronic sinobronchial syndrome.

摘要

背景

是一种环境性黑真菌，很少引起呼吸道感染，但其病理生理特征和治疗方案尚未确定。

病例系列

介绍了日本两例因感染导致慢性支气管炎和鼻窦炎加重的病例。两名患者均为女性，根据胸部影像学检查结果怀疑为非结核分枝杆菌（NTM）感染，但分别从支气管灌洗液和鼻黏液中检测到。两例均通过脂质体两性霉素B、伏立康唑和伊曲康唑等抗真菌药物成功治疗，但用于NTM的克拉霉素、利福平、乙胺丁醇和西他沙星无效。

结论

可成为呼吸道病原体，尤其是在慢性鼻窦支气管综合征患者中。

需注意，原文中部分关键信息缺失，如具体的真菌名称未完整给出，可能会影响译文的准确性和流畅性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99dc/8948093/bfa423b442dc/IDR-15-1135-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99dc/8948093/14da46452fe9/IDR-15-1135-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99dc/8948093/2f279f3d5993/IDR-15-1135-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99dc/8948093/5c8f71a8d39d/IDR-15-1135-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99dc/8948093/bfa423b442dc/IDR-15-1135-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99dc/8948093/14da46452fe9/IDR-15-1135-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99dc/8948093/2f279f3d5993/IDR-15-1135-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99dc/8948093/5c8f71a8d39d/IDR-15-1135-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99dc/8948093/bfa423b442dc/IDR-15-1135-g0004.jpg

相似文献

1
Sinobronchial Syndrome Patients with Suspected Non-Tuberculous Infection Exacerbated by Infection.疑似非结核感染加重的中华支气管综合征患者。
Infect Drug Resist. 2022 Mar 20;15:1135-1141. doi: 10.2147/IDR.S359646. eCollection 2022.
2
pneumonia with bronchiectasis required prolonged voriconazole treatment.合并支气管扩张的肺炎需要长期伏立康唑治疗。
Respirol Case Rep. 2021 May 25;9(6):e00783. doi: 10.1002/rcr2.783. eCollection 2021 Jun.
3
Pulmonary phaeohyphomycosis due to Exophiala dermatitidis in a patient with pulmonary non-tuberculous mycobacterial infection.一名患有肺部非结核分枝杆菌感染的患者发生由皮炎外瓶霉引起的肺部暗色丝孢霉病。
J Infect Chemother. 2023 Jun;29(6):615-619. doi: 10.1016/j.jiac.2023.03.010. Epub 2023 Mar 13.
4
Antifungal activity of antifungal drugs, as well as drug combinations against Exophiala dermatitidis.抗真菌药物的抗真菌活性，以及针对皮炎外瓶霉的药物联合治疗。
Mycopathologia. 2011 Feb;171(2):111-7. doi: 10.1007/s11046-010-9358-6. Epub 2010 Aug 29.
5
coinfection with nontuberculous mycobacteria: A case report and literature review.非结核分枝杆菌合并感染：一例病例报告及文献综述。
Respirol Case Rep. 2023 Sep 13;11(10):e01221. doi: 10.1002/rcr2.1221. eCollection 2023 Oct.
6
Exophiala dermatitidis pneumonia successfully treated with long-term itraconazole therapy.采用长期伊曲康唑治疗成功治愈皮炎外瓶霉肺炎。
J Infect Chemother. 2014 Jul;20(7):446-9. doi: 10.1016/j.jiac.2014.02.006. Epub 2014 Apr 22.
7
Exophiala dermatitidis as a cause of central line associated bloodstream infection in an infant: Case report and literature review.皮炎外瓶霉作为婴儿中心静脉导管相关血流感染的病因：病例报告及文献综述
Rev Iberoam Micol. 2021 Jan-Mar;38(1):12-15. doi: 10.1016/j.riam.2020.09.004. Epub 2020 Dec 3.
8
Disseminated Exophiala dermatitidis causing septic arthritis and osteomyelitis.播散性皮炎外瓶霉引起的化脓性关节炎和骨髓炎。
BMC Infect Dis. 2018 Jun 4;18(1):255. doi: 10.1186/s12879-018-3171-0.
9
High rate of Exophiala dermatitidis recovery in the airways of patients with cystic fibrosis is associated with pancreatic insufficiency.在囊性纤维化患者的气道中，外瓶霉的回收率很高，这与胰腺功能不全有关。
J Clin Microbiol. 2011 Mar;49(3):1004-9. doi: 10.1128/JCM.01899-10. Epub 2011 Jan 5.
10
A fatal case of Exophiala dermatitidis meningoencephalitis in an immunocompetent host: A case report and literature review.免疫功能正常宿主中皮炎外瓶霉脑膜脑炎致死性病例：病例报告及文献复习。
J Infect Chemother. 2021 Oct;27(10):1520-1524. doi: 10.1016/j.jiac.2021.06.014. Epub 2021 Jun 30.

引用本文的文献

1
A Rare Case of Exophiala Dermatitidis Isolation in a Patient with Non-Cystic Fibrosis Bronchiectasis: Colonization or True Infection?非囊性纤维化支气管扩张患者分离出皮炎外瓶霉1例罕见病例：定植还是真正感染？
Diagnostics (Basel). 2025 Jun 29;15(13):1661. doi: 10.3390/diagnostics15131661.
2
Exploring a Rare Pulmonary Coinfection: Cryptococcal Pneumonia and Exophiala dermatitidis in an Immunocompetent Host.探索一种罕见的肺部合并感染：免疫功能正常宿主中的隐球菌性肺炎和皮炎外瓶霉感染
Cureus. 2024 May 25;16(5):e61085. doi: 10.7759/cureus.61085. eCollection 2024 May.
3
coinfection with nontuberculous mycobacteria: A case report and literature review.

本文引用的文献

1
Exophiala dermatitidis.皮炎外瓶霉
World J Clin Cases. 2021 Sep 26;9(27):7963-7972. doi: 10.12998/wjcc.v9.i27.7963.
2
pneumonia with bronchiectasis required prolonged voriconazole treatment.合并支气管扩张的肺炎需要长期伏立康唑治疗。
Respirol Case Rep. 2021 May 25;9(6):e00783. doi: 10.1002/rcr2.783. eCollection 2021 Jun.
3
: Key issues of an opportunistic fungal pathogen.机遇性真菌病原体的关键问题。
非结核分枝杆菌合并感染：一例病例报告及文献综述。
Respirol Case Rep. 2023 Sep 13;11(10):e01221. doi: 10.1002/rcr2.1221. eCollection 2023 Oct.
4
Detection of Complex (MAC) by Bronchial Lavage and the Relationship with Titers of Anti-Glycopeptidolipid-Core IgA Antibodies to MAC in Patients with Pulmonary MAC Disease.支气管灌洗检测肺部MAC病患者的复合分枝杆菌（MAC）及其与抗糖脂核心IgA抗体滴度的关系
Infect Drug Resist. 2023 Feb 17;16:977-984. doi: 10.2147/IDR.S400200. eCollection 2023.
Virulence. 2019 Dec;10(1):984-998. doi: 10.1080/21505594.2019.1596504. Epub 2019 Apr 3.
4
Molecular diagnostics in medical mycology.医学真菌学中的分子诊断。
Nat Commun. 2018 Dec 3;9(1):5135. doi: 10.1038/s41467-018-07556-5.
5
Evaluation of blood culture broths with lysis buffer to directly identify specific pathogens by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry methods.使用裂解缓冲液的血培养肉汤通过基质辅助激光解吸/电离飞行时间质谱法直接鉴定特定病原体的评估。
Infect Drug Resist. 2018 Sep 24;11:1573-1579. doi: 10.2147/IDR.S169197. eCollection 2018.
6
Synergistic Effects of Tacrolimus and Azoles against Exophiala dermatitidis.他克莫司与唑类药物联合抗皮炎外瓶霉的协同作用。
Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.00948-17. Print 2017 Dec.
7
Usefulness of matrix-assisted laser desorption ionization time-of-flight mass spectrometry to identify pathogens, including polymicrobial samples, directly from blood culture broths.基质辅助激光解吸电离飞行时间质谱直接从血培养肉汤中鉴定病原体（包括混合微生物样本）的实用性。
Infect Drug Resist. 2017 Apr 19;10:115-120. doi: 10.2147/IDR.S132931. eCollection 2017.
8
Biofilm formation of the black yeast-like fungus Exophiala dermatitidis and its susceptibility to antiinfective agents.黑酵母样真菌皮炎外瓶霉的生物膜形成及其对抗感染药物的敏感性。
Sci Rep. 2017 Feb 17;7:42886. doi: 10.1038/srep42886.
9
Burkholderia cepacia selective agar can be useful for recovery of Exophiala dermatitidis from sputum samples of cystic fibrosis patients.洋葱伯克霍尔德菌选择性琼脂可用于从囊性纤维化患者的痰液样本中分离出皮炎外瓶霉。
J Cyst Fibros. 2016 Mar;15(2):e19. doi: 10.1016/j.jcf.2015.12.021. Epub 2016 Jan 14.
10
Analyses of black fungi by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS): species-level identification of clinical isolates of Exophiala dermatitidis.基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF MS）分析黑色真菌：皮炎外瓶霉临床分离株的种水平鉴定
FEMS Microbiol Lett. 2015 Jan;362(1):1-6. doi: 10.1093/femsle/fnu016. Epub 2014 Dec 4.