狭叶虎皮楠中具有细胞毒性活性的虎皮楠生物碱。

Daphniphyllum alkaloids with cytotoxic activity from Daphniphyllum angustifolium.

作者信息

Liu Shuai, Zhang Jiahui, Di Yingtong, Dong Jinyan, Hao Xiaojiang

机构信息

a School of Life Sciences , Southwest University , Chongqing , China.

b State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.

出版信息

Nat Prod Res. 2018 Sep;32(18):2165-2170. doi: 10.1080/14786419.2017.1371155. Epub 2017 Sep 19.

DOI:10.1080/14786419.2017.1371155

PMID:28927287

Abstract

A new Daphniphyllum alkaloid, daphnezomine W (1), together with four known ones, were isolated from the stems of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 1 was a new daphnezomine L-type alkaloid and exhibited moderate cytotoxic activity against Hela cell line with IC of 16.0 μg/mL. A plausible biosynthetic pathway of 1 was also proposed.

摘要

从狭叶虎皮楠（Daphniphyllum angustifolium Hutch.）的茎中分离出一种新的虎皮楠生物碱——虎皮楠胺W（1），以及四种已知生物碱。通过光谱方法并与文献数据对比确定了它们的结构。化合物1是一种新的虎皮楠胺L型生物碱，对Hela细胞系表现出中等细胞毒性活性，IC50为16.0 μg/mL。还提出了化合物1可能的生物合成途径。