Tabatabaei Qomi Reza, Sheykhhasan Mohsen
Department of Stem Cell, the Academic Center for Education, Culture and Research, PO Box QOM-3713189934, Qom, Iran.
World J Stem Cells. 2017 Aug 26;9(8):107-117. doi: 10.4252/wjsc.v9.i8.107.
The application of appropriate cell origin for utilizing in regenerative medicine is the major issue. Various kinds of stem cells have been used for the tissue engineering and regenerative medicine. Such as, several stromal cells have been employed as treat option for regenerative medicine. For example, human bone marrow-derived stromal cells and adipose-derived stromal cells (ADSCs) are used in cell-based therapy. Data relating to the stem cell therapy and processes associated with ADSC has developed remarkably in the past 10 years. As medical options, both the stromal vascular and ADSC suggests good opportunity as marvelous cell-based therapeutics. The some biological features are the main factors that impact the regenerative activity of ADSCs, including the modulation of the cellular immune system properties and secretion of bioactive proteins such as cytokines, chemokines and growth factors, as well as their intrinsic anti-ulcer and anti-inflammatory potential. A variety of diseases have been treated by ADSCs, and it is not surprising that there has been great interest in the possibility that ADSCs might be used as therapeutic strategy to improve a wider range of diseases. This is especially important when it is remembered that routine therapeutic methods are not completely effective in treat of diseases. Here, it was discuss about applications of ADSC to colitis, liver failure, diabetes mellitus, multiple sclerosis, orthopaedic disorders, hair loss, fertility problems, and salivary gland damage.
在再生医学中应用合适的细胞来源是主要问题。多种干细胞已被用于组织工程和再生医学。例如，几种基质细胞已被用作再生医学的治疗选择。例如，人骨髓来源的基质细胞和脂肪来源的基质细胞（ADSCs）被用于基于细胞的治疗。在过去10年中，与干细胞治疗及与ADSC相关的过程的数据有了显著发展。作为医学选择，基质血管细胞和ADSCs都显示出作为出色的基于细胞的治疗方法的良好机会。一些生物学特性是影响ADSCs再生活性的主要因素，包括调节细胞免疫系统特性、分泌生物活性蛋白如细胞因子、趋化因子和生长因子，以及它们固有的抗溃疡和抗炎潜力。多种疾病已通过ADSCs进行治疗，ADSCs可能被用作改善更广泛疾病的治疗策略这一可能性引发了极大兴趣也就不足为奇了。当人们记住常规治疗方法在治疗疾病方面并不完全有效时，这一点尤为重要。在此，讨论了ADSC在结肠炎、肝衰竭、糖尿病、多发性硬化症、骨科疾病、脱发、生育问题和唾液腺损伤中的应用。
