激酶 MPK17 和过氧化物酶体分裂因子 PMD1 影响盐诱导的过氧化物酶体增殖。
Kinase MPK17 and the Peroxisome Division Factor PMD1 Influence Salt-induced Peroxisome Proliferation.
机构信息
Department of Biology, Washington University in St. Louis, St. Louis, Missouri.
Department of Biology, Washington University in St. Louis, St. Louis, Missouri
出版信息
Plant Physiol. 2018 Jan;176(1):340-351. doi: 10.1104/pp.17.01019. Epub 2017 Sep 20.
Abstract
Peroxisomes are small organelles that house many oxidative reactions. Peroxisome proliferation is induced under multiple stress conditions, including salt stress; however, factors regulating this process are not well defined. We have identified a role for Arabidopsis () MAP KINASE17 (MPK17) in affecting peroxisome division in a manner that requires the known peroxisome division factor PEROXISOME AND MITOCHONDRIAL DIVISION FACTOR1 (PMD1). MPK17 and PMD1 are involved in peroxisome proliferation in response to NaCl stress. Additionally, we found that PMD1 is an actin-binding protein and that a functioning actin cytoskeleton is required for NaCl-induced peroxisome division. Our data suggest roles for MPK17 and PMD1 in influencing the numbers and cellular distribution of peroxisomes through the cytoskeleton-peroxisome connection. These findings expand our understanding of peroxisome division and potentially identify factors connecting the actin cytoskeleton and peroxisome proliferation.
摘要
过氧化物酶体是一种小型细胞器，其中包含许多氧化反应。过氧化物酶体增殖是在多种应激条件下诱导的，包括盐胁迫；然而，调节这个过程的因素还没有很好地定义。我们已经确定了拟南芥（Arabidopsis）MAP KINASE17（MPK17）在以依赖于已知的过氧化物酶体分裂因子 PEROXISOME AND MITOCHONDRIAL DIVISION FACTOR1（PMD1）的方式影响过氧化物酶体分裂中的作用。MPK17 和 PMD1 参与了对 NaCl 胁迫的过氧化物酶体增殖。此外，我们发现 PMD1 是一种肌动蛋白结合蛋白，并且功能正常的肌动蛋白细胞骨架对于 NaCl 诱导的过氧化物酶体分裂是必需的。我们的数据表明，MPK17 和 PMD1 通过细胞骨架-过氧化物酶体连接，在影响过氧化物酶体的数量和细胞分布方面发挥作用。这些发现扩展了我们对过氧化物酶体分裂的理解，并可能确定了连接肌动蛋白细胞骨架和过氧化物酶体增殖的因素。
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2
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