口腔黏膜下纤维化患者焦虑、抑郁及血清皮质醇水平的评估：一项对照临床试验。
Assessment of anxiety, depression, and serum cortisol level in oral submucous fibrosis patients: A controlled clinical trial.
作者信息
Kanodia Shubhra, Giri Vishal Prakash, Giri Om Prakash, Devi M Parvathi, Garima Y
机构信息
Department of Dentistry, Sri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, India.
Department of Pharmacology, Sri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, India.
出版信息
Eur J Dent. 2017 Jul-Sep;11(3):293-298. doi: 10.4103/ejd.ejd_9_17.
OBJECTIVE
The aim of this study was to assess the anxiety, depression, and serum cortisol level in OSMF patients.
MATERIALS AND METHODS
This cross-sectional study was conducted in the Outpatient Department of Oral Medicine and Radiology, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India. Age- and gender-matched 105 patients were divided into three equal groups as follows: Group 1 - those with areca nut chewing habits and OSMF, Group 2 - those with areca nut chewing habits but no OSMF, and Group 3- those without areca nut chewing habits and without OSMF. Anxiety and depression were assessed by the Hamilton Anxiety Rating Scale and the Hamilton Depression Rating Scale, respectively. Serum cortisol level was also measured simultaneously.
STATISTICAL ANALYSIS
Paired -test, Chi-square test, and analysis of variance were used.
RESULTS
Fifty (47.62%) patients were observed to be in the age group of 25-32 years. Ninety-six (91.4%) patients were males and 9 (8.6%) were females. The mean serum cortisol level was observed to be higher among patients with OSMF-C followed by those with OSMF-D.
CONCLUSION
We conclude that there is a significant association between OSMF, depression, and serum cortisol level.
目的
本研究旨在评估口腔黏膜下纤维化（OSMF）患者的焦虑、抑郁及血清皮质醇水平。
材料与方法
本横断面研究在印度北方邦莫拉达巴德蒂尔坦克·马哈维尔牙科学院及研究中心口腔医学与放射科门诊进行。将105例年龄和性别匹配的患者分为三组，每组人数相等，如下：第1组——有槟榔咀嚼习惯且患有OSMF的患者；第2组——有槟榔咀嚼习惯但未患OSMF的患者；第3组——无槟榔咀嚼习惯且未患OSMF的患者。分别采用汉密尔顿焦虑评定量表和汉密尔顿抑郁评定量表评估焦虑和抑郁情况。同时测量血清皮质醇水平。
统计分析
采用配对t检验、卡方检验和方差分析。
结果
观察到50例（47.62%）患者年龄在25 - 32岁之间。96例（91.4%）患者为男性，9例（8.6%）为女性。观察发现，OSMF - C患者的平均血清皮质醇水平最高，其次是OSMF - D患者。
结论
我们得出结论，OSMF、抑郁和血清皮质醇水平之间存在显著关联。
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