College of Horticulture, Qingdao Agricultural University, Qingdao 266109, China.
College of Chemistry and Pharmacy, Qingdao Agricultural University, Qingdao 266109, China.
Molecules. 2017 Sep 21;22(10):1562. doi: 10.3390/molecules22101562.
One new and three known triterpenoid saponins were isolated and identified from seeds through IR, NMR, HR-ESI-MS and GC-MS spectroscopic methods, namely oleiferasaponin A₃, oleiferasaponin A₁, camelliasaponin B₁, and camelliasaponin B₂. The structure of oleiferasaponin A₃ was elucidated as 16α-hydroxy-21β--angeloyl-22α--cinnamoyl-23α-aldehyde-28-dihydroxymethylene-olean-12-ene-3β--[β-d-galactopyranosyl-(1→2)]-[β-d-xylopyranosyl-(1→2)-β-d-galactopyranosyl-(1→3)]-β-d-gluco-pyranosiduronic acid. Camelliasaponin B₁ and camelliasaponin B₂ exhibited potent cytotoxic activity on three human tumour cell lines (human lung tumour cells (A549), human liver tumour cells (HepG2), cervical tumour cells (Hela)). The hypoglycemic activity of oleiferasaponin A₁ was testified by protecting pancreatic β-cell lines from high-glucose damage.
从种子中通过 IR、NMR、HR-ESI-MS 和 GC-MS 光谱方法分离并鉴定了一种新的和三种已知的三萜皂苷，分别为 oleiferasaponin A₃、oleiferasaponin A₁、camelliasaponin B₁ 和 camelliasaponin B₂。oleiferasaponin A₃的结构被阐明为 16α-羟基-21β--当归酰基-22α--肉桂酰基-23α-醛-28-二羟亚甲基-齐墩烷-12-烯-3β--[β-d-半乳糖吡喃基-(1→2)]-[β-d-木糖吡喃基-(1→2)-β-d-半乳糖吡喃基-(1→3)]-β-d-葡萄糖吡喃酸。Camelliasaponin B₁ 和 camelliasaponin B₂ 对三种人类肿瘤细胞系（人肺癌细胞 (A549)、人肝癌细胞 (HepG2)、宫颈癌细胞 (Hela)）表现出很强的细胞毒性。oleiferasaponin A₁ 的降血糖活性通过保护胰岛β细胞系免受高葡萄糖损伤得到证实。
