从替代动物模型视角看肿瘤免疫学——故事篇
Tumor immunology viewed from alternative animal models-the story.
作者信息
Banach Maureen, Robert Jacques
机构信息
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, USA.
出版信息
Curr Pathobiol Rep. 2017 Mar;5(1):49-56. doi: 10.1007/s40139-017-0125-y. Epub 2017 Jan 26.
A PURPOSE OF REVIEW
Nonmammalian comparative animal models are important not only to gain fundamental evolutionary understanding of the complex interactions of tumors with the immune system, but also to better predict the applicability of novel immunotherapeutic approaches to humans. After reviewing recent advances in developing alternative models, we focus on the amphibian and its usefulness in deciphering the perplexing roles of MHC class I-like molecules and innate (i)T cells in tumor immunity.
B RECENT FINDINGS
Experiments using MHC-defined inbred and cloned animals, tumor cell lines, effective reagents, sequenced genomes, and adapted gene editing techniques in , have revealed that the critical involvement of class I-like molecules and iT cells in tumor immunity has been conserved during evolution.
C SUMMARY
Comparative studies with the tumor immunity model can contribute to the development of better and more efficient cancer immunotherapies.
A 综述目的：非哺乳动物比较动物模型不仅对于深入了解肿瘤与免疫系统复杂相互作用的基本进化过程至关重要，而且对于更好地预测新型免疫治疗方法在人类中的适用性也很重要。在回顾了开发替代模型的最新进展后，我们重点关注两栖动物及其在解读MHC I类样分子和固有（i）T细胞在肿瘤免疫中令人困惑的作用方面的实用性。
B 最新发现：在[具体动物]中使用MHC定义的近交系和克隆动物、肿瘤细胞系、有效试剂、测序基因组以及适用的基因编辑技术进行的实验表明，I类样分子和iT细胞在肿瘤免疫中的关键参与在进化过程中一直存在。
C 总结：与[具体动物]肿瘤免疫模型的比较研究有助于开发更好且更有效的癌症免疫疗法。
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