Muñoz-Cabello Patricia, García-Miñaúr Sixto, Espinel-Vallejo Manuel Eliecer, Fernández-Franco Lorenzo, Stephens Alexandra, Santos-Simarro Fernando, Lapunzina-Badía Pablo, McAllister Marion
Sección de Genética Clínica, Instituto de Genética Médica y Molecular (INGEMM), Hospital Universitario La Paz, Paseo Castellana, 261, E-28046, Madrid, Spain.
Unidad 753, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
J Genet Couns. 2018 Jun;27(3):732-743. doi: 10.1007/s10897-017-0154-z. Epub 2017 Sep 25.
The aim in this study was to translate and cross-culturally adapt the Genetic Counseling Outcome Scale (GCOS-24) for use in Spain and to carry out a preliminary psychometric validation in a sample of Spanish patients. With oversight by an expert panel, forward and backward translations were conducted to create the draft Spanish GCOS-24. Fourteen patients were recruited from a clinical genetics service in Madrid, Spain, to participate in cognitive interviews designed to explore readability and interpretability of the draft. Following qualitative analysis of interview transcripts, a final version of the Spanish GCOS-24 was agreed with the expert panel. No significant cross-cultural differences were identified. The Spanish GCOS-24 was then completed prior to and 2-4 weeks after genetic counseling by 59 patients attending the service, and data were analysed using analysis of variance. Preliminary psychometric validation of the Spanish GCOS-24 showed significantly higher GCOS-24 scores after genetic counseling (p < 0.0001), with good internal consistency (α = 0.84) and sensitivity to change over time, with a medium-to-large size effect (Cohen's d = 0.70). This compares well with the original English language GCOS-24. Findings demonstrate that the Spanish GCOS-24 has potential for use in evaluating clinical genetics services in Spain, but would benefit from assessment of test-retest reliability as well as structural and construct validity.
本研究的目的是翻译并对遗传咨询结果量表（GCOS - 24）进行跨文化调适，以便在西班牙使用，并在一组西班牙患者样本中进行初步的心理测量学验证。在一个专家小组的监督下，进行了正向和反向翻译，以创建西班牙文版GCOS - 24草案。从西班牙马德里的一家临床遗传学服务机构招募了14名患者，参与旨在探索该草案的可读性和可解释性的认知访谈。在对访谈记录进行定性分析之后，与专家小组商定了西班牙文版GCOS - 24的最终版本。未发现显著的跨文化差异。随后，该服务机构的59名患者在遗传咨询前和咨询后2 - 4周完成了西班牙文版GCOS - 24的填写，并使用方差分析对数据进行了分析。西班牙文版GCOS - 24的初步心理测量学验证显示，遗传咨询后GCOS - 24得分显著更高（p < 0.0001），具有良好的内部一致性（α = 0.84），并且对随时间的变化具有敏感性，效应量为中到大型（科恩d值 = 0.70）。这与原始英文版GCOS - 24相比表现良好。研究结果表明，西班牙文版GCOS - 24在评估西班牙的临床遗传学服务方面具有应用潜力，但还需要评估重测信度以及结构效度和构想效度。
