LIBPhys (Laboratory for Instrumentation, Biomedical Engineering and Radiation Physics), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516, Caparica, Portugal.
Laboratory of Motor Behaviour, CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Estrada da Costa, 1499-002, Cruz Quebrada - Dafundo, Portugal.
Biomed Eng Online. 2017 Sep 25;16(1):115. doi: 10.1186/s12938-017-0405-0.
Modeling physiological signals is a complex task both for understanding and synthesize biomedical signals. We propose a deep neural network model that learns and synthesizes biosignals, validated by the morphological equivalence of the original ones. This research could lead the creation of novel algorithms for signal reconstruction in heavily noisy data and source detection in biomedical engineering field.
The present work explores the gated recurrent units (GRU) employed in the training of respiration (RESP), electromyograms (EMG) and electrocardiograms (ECG). Each signal is pre-processed, segmented and quantized in a specific number of classes, corresponding to the amplitude of each sample and fed to the model, which is composed by an embedded matrix, three GRU blocks and a softmax function. This network is trained by adjusting its internal parameters, acquiring the representation of the abstract notion of the next value based on the previous ones. The simulated signal was generated by forecasting a random value and re-feeding itself.
The resulting generated signals are similar with the morphological expression of the originals. During the learning process, after a set of iterations, the model starts to grasp the basic morphological characteristics of the signal and later their cyclic characteristics. After training, these models' prediction are closer to the signals that trained them, specially the RESP and ECG. This synthesis mechanism has shown relevant results that inspire the use to characterize signals from other physiological sources.
对生理信号进行建模既是理解也是合成生物医学信号的一项复杂任务。我们提出了一种深度学习神经网络模型,该模型通过原始信号的形态等效性来学习和合成生物信号,并对其进行了验证。这项研究可以为生物医学工程领域中在强噪声数据中进行信号重构和源检测的新型算法的创建奠定基础。
本研究探索了门控循环单元(GRU)在呼吸(RESP)、肌电图(EMG)和心电图(ECG)训练中的应用。每个信号都经过预处理、分割和量化为特定数量的类别,对应于每个样本的幅度,并输入到模型中,该模型由一个嵌入式矩阵、三个 GRU 块和一个 softmax 函数组成。该网络通过调整其内部参数进行训练,根据前一个值获取下一个值的抽象概念表示。通过预测随机值并重新输入来生成模拟信号。
生成的信号与原始信号的形态表达相似。在学习过程中,经过一组迭代后,模型开始掌握信号的基本形态特征,然后是它们的循环特征。训练后,这些模型的预测与训练它们的信号更加接近,特别是 RESP 和 ECG。这种合成机制已经显示出相关的结果,为使用其他生理源的信号特征提供了启示。