Giannaki Christoforos D, Hadjigavriel Michael, Lazarou Akis, Michael Aristos, Damianou Loukas, Atmatzidis Efthimios, Stefanidis Ioannis, Hadjigeorgiou Georgios M, Sakkas Giorgos K, Pantzaris Marios
Department of Life and Health Sciences, University of Nicosia, Nicosia CY 1700, Cyprus.
Hemodialysis Unit, Larnaca General Hospital, Larnaca CY 6021, Cyprus.
World J Nephrol. 2017 Sep 6;6(5):236-242. doi: 10.5527/wjn.v6.i5.236.
To examine whether hemodialysis (HD) patients with restless legs syndrome (RLS) are subjects of greater fatigue and impaired quality of life (QoL) compared to HD patients without RLS.
Eighty five stable HD patients participated in this study. According to their RLS status, the patients were divided into the RLS group ( = 23) and the non-RLS group ( = 62). QoL, fatigue, sleep quality, daily sleepiness and depression symptoms were assessed by using various questionnaires. Finally, biochemical parameters including iron, ferritin, hemoglobin, hematocrit and parathormone were assessed.
The HD patients with RLS scored worse in all the questionnaires used in the study ( < 0.05). The patients with RLS were more likely to receive the HD therapy on the morning shift, whilst 43.5% of the RLS patients reported to experience the RLS symptoms also during HD. The severity of RLS was correlated with fatigue, depression score and sleep quality ( < 0.05).
HD patients with RLS are subject to lower QoL related parameters and greater fatigue compared to HD patients without RLS. RLS should be successfully managed in order to improve the QoL of the sufferers.
研究与无不安腿综合征（RLS）的血液透析（HD）患者相比，患有RLS的HD患者是否更容易出现疲劳和生活质量（QoL）受损。
85名稳定的HD患者参与了本研究。根据他们的RLS状态，患者被分为RLS组（n = 23）和非RLS组（n = 62）。使用各种问卷评估生活质量、疲劳、睡眠质量、日间嗜睡和抑郁症状。最后，评估包括铁、铁蛋白、血红蛋白、血细胞比容和甲状旁腺激素在内的生化参数。
患有RLS的HD患者在本研究中使用的所有问卷中得分更低（P < 0.05）。患有RLS的患者更有可能接受早班的HD治疗，而43.5%的RLS患者报告在HD期间也出现RLS症状。RLS的严重程度与疲劳、抑郁评分和睡眠质量相关（P < 0.05）。
与无RLS的HD患者相比，患有RLS的HD患者的生活质量相关参数更低，疲劳程度更高。应成功管理RLS以改善患者的生活质量。
