载姜黄素醋酸邻苯二甲酸纤维素聚合物的非织造电纺纳米纤维的制备、表征及扩散研究
Preparation, characterization, and diffusion study of nonwoven electrospun nanofiber of curcumin-loaded cellulose acetate phthalate polymer.
作者信息
Ravikumar Rramaswamy, Ganesh Mani, Ubaidulla Udumansha, Young Choi Eun, Tae Jang Hyun
机构信息
Department of Chemical Engineering, Hanseo University, 360 Daegok-ri, Seosan-si 356 706, Chungcheongnam-do, South Korea.
Department of Advanced Materials and Engineering, Hanseo University, 360 Daegok-ri, Seosan-si 356 706, Chungcheongnam-do, South Korea.
出版信息
Saudi Pharm J. 2017 Sep;25(6):921-926. doi: 10.1016/j.jsps.2017.02.004. Epub 2017 Feb 12.
Novel curcumin (CUR)-loaded cellulose acetate phthalate (CAP) nonwoven electrospun nanofiber (NF) transdermal mat was developed and evaluated for its CUR diffusion properties. Various CAP solutions from 5 to 20 wt% were tested; 17.5 wt% was found to be a suitable concentration for NF fabrication without defects, such as bubble or ribbon structures. The selected wt% CAP solution was loaded with CUR and electrospun into NFs. The prepared CUR-loaded NFs were characterized using scanning electron microscopy, X-ray diffraction, ultraviolet-visible spectroscopy, thermogravimetric analysis (TGA), and diffusion studies. The as-prepared fibers demonstrated controlled transdermal delivery of CUR for up to 24 h.
开发了新型载姜黄素（CUR）的邻苯二甲酸醋酸纤维素（CAP）非织造电纺纳米纤维（NF）透皮垫，并对其姜黄素扩散特性进行了评估。测试了5至20 wt%的各种CAP溶液；发现17.5 wt%是用于制造无气泡或带状结构等缺陷的纳米纤维的合适浓度。将选定重量百分比的CAP溶液加载姜黄素并电纺成纳米纤维。使用扫描电子显微镜、X射线衍射、紫外可见光谱、热重分析（TGA）和扩散研究对制备的载姜黄素纳米纤维进行了表征。所制备的纤维显示出长达24小时的可控姜黄素透皮递送。
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