Ravikumar Rramaswamy, Ganesh Mani, Ubaidulla Udumansha, Young Choi Eun, Tae Jang Hyun
Department of Chemical Engineering, Hanseo University, 360 Daegok-ri, Seosan-si 356 706, Chungcheongnam-do, South Korea.
Department of Advanced Materials and Engineering, Hanseo University, 360 Daegok-ri, Seosan-si 356 706, Chungcheongnam-do, South Korea.
Saudi Pharm J. 2017 Sep;25(6):921-926. doi: 10.1016/j.jsps.2017.02.004. Epub 2017 Feb 12.
Novel curcumin (CUR)-loaded cellulose acetate phthalate (CAP) nonwoven electrospun nanofiber (NF) transdermal mat was developed and evaluated for its CUR diffusion properties. Various CAP solutions from 5 to 20 wt% were tested; 17.5 wt% was found to be a suitable concentration for NF fabrication without defects, such as bubble or ribbon structures. The selected wt% CAP solution was loaded with CUR and electrospun into NFs. The prepared CUR-loaded NFs were characterized using scanning electron microscopy, X-ray diffraction, ultraviolet-visible spectroscopy, thermogravimetric analysis (TGA), and diffusion studies. The as-prepared fibers demonstrated controlled transdermal delivery of CUR for up to 24 h.
开发了新型载姜黄素（CUR）的邻苯二甲酸醋酸纤维素（CAP）非织造电纺纳米纤维（NF）透皮垫，并对其姜黄素扩散特性进行了评估。测试了5至20 wt%的各种CAP溶液；发现17.5 wt%是用于制造无气泡或带状结构等缺陷的纳米纤维的合适浓度。将选定重量百分比的CAP溶液加载姜黄素并电纺成纳米纤维。使用扫描电子显微镜、X射线衍射、紫外可见光谱、热重分析（TGA）和扩散研究对制备的载姜黄素纳米纤维进行了表征。所制备的纤维显示出长达24小时的可控姜黄素透皮递送。
