Department of Biomedical Engineering, Center for Biomedical Imaging Research, Tsinghua University School of Medicine, Beijing, China.
Department of Radiology, University of Washington, Seattle, Washington, USA.
Stroke Vasc Neurol. 2017 Feb 24;2(1):15-20. doi: 10.1136/svn-2016-000053. eCollection 2017 Mar.
Carotid atherosclerotic plaque is identified as one of the main sources of ischaemic stroke. However, the prevalence of carotid high-risk atherosclerotic plaque in Chinese patients with ischaemic cerebrovascular events has been inconsistently reported and needs to be investigated in a large population.
The primary objective of CARE II study was to determine the prevalence and characteristics of high-risk features of atherosclerotic plaques in the carotid arteries in Chinese patients with recent ischaemic stroke or transient ischaemia attack (TIA). The relationship between carotid plaque features and cerebral infarcts, the differences of carotid plaque patterns among different regions of China and the gender specific characteristics of carotid plaque will be also determined.
The CARE II study will enrol 1000 patients with recent ischaemic stroke or TIA and carotid plaque from 13 hospitals and medical centres across China. In this cross-sectional, non-randomised, observational, multicentre study, all patients will undergo carotid artery MRI of bilateral carotid arteries and routine brain MRI with standardised protocols. The MRI will be interpreted at core reading centres to evaluate the characteristics of morphology and compositions of carotid plaque.
This is a cross-sectional, multicentre study to investigate the prevalence and characteristics of high-risk atherosclerotic carotid plaque in Chinese patients with stroke and TIA by using high-resolution MRI of vessel wall. This trial is sufficiently powered to demonstrate the prevalence of carotid high-risk plaque and to explore regional differences in Chinese patients who suffered stroke.
NCT02017756.
颈动脉粥样硬化斑块被认为是缺血性卒中的主要病因之一。然而，中国缺血性脑血管病患者颈动脉高危粥样硬化斑块的发生率报道结果并不一致，需要在大样本人群中进行调查。
CARE II 研究的主要目的是明确中国近期发生缺血性卒中和短暂性脑缺血发作（TIA）患者颈动脉粥样硬化斑块的高危特征的发生率和特点。我们还将确定颈动脉斑块特征与脑梗死之间的关系，不同地区间颈动脉斑块模式的差异以及颈动脉斑块的性别特异性特征。
CARE II 研究将纳入 1000 例来自中国 13 家医院和医疗中心的近期发生缺血性卒中和 TIA 且伴颈动脉斑块的患者。这是一项横断面、非随机、观察性、多中心研究，所有患者均将接受双侧颈动脉 MRI 及标准方案的常规脑部 MRI 检查。将在核心阅读中心对 MRI 进行解读，以评估颈动脉斑块形态和成分的特点。
这是一项横断面、多中心研究，旨在通过高分辨率血管壁 MRI 检查，调查中国缺血性卒中和 TIA 患者中高危颈动脉粥样硬化斑块的发生率和特点。该试验具有足够的效能来显示颈动脉高危斑块的发生率，并探索中国卒中患者的区域性差异。
NCT02017756。
