Lesser Mary N R, Keen Carl L, Lanoue Louise
Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609, United States.
Department of Nutritional Sciences & Toxicology, University of California, Berkeley, 119 Morgan Hall, Berkeley, CA 94720, United States.
Toxicol Rep. 2015 Jan 10;2:443-449. doi: 10.1016/j.toxrep.2015.01.003. eCollection 2015.
Maternal nutrition can have a significant effect on developmental processes during pregnancy and lactation. While certain flavonoids have been postulated to be beneficial for health, little is known about the effects of ingestion during pregnancy and lactation on the mother and progeny. We report on the effects of maternal consumption of high levels of certain flavonoids on reproductive and developmental outcomes in a mouse model. C57BL/6J female mice were fed a control diet (CT), the CT diet supplemented with 1% or 2% of a mix of epicatechin and catechin (EC1, EC2), or rutin (RU1, RU2) prior to, during pregnancy, and lactation. A subset of dams was killed on gestation day (GD) 18.5 to evaluate fetal outcomes and the remainder was allowed to deliver to evaluate offspring. Maternal food intake, body and tissue weight did not differ among groups. The number of resorptions, implantations, litter size, postnatal survival, body weight, and skeletal development were also similar. Alterations in maternal and offspring liver mineral concentrations were observed. The current results indicate that consumption of high amounts of epicatechin, catechin, and rutin during gestation and lactation is not associated with any marked developmental effects, although changes in liver mineral concentrations were noted.
母体营养对怀孕和哺乳期间的发育过程可能有重大影响。虽然某些黄酮类化合物被认为对健康有益，但关于孕期和哺乳期摄入这些化合物对母体和后代的影响却知之甚少。我们报告了母体摄入高水平特定黄酮类化合物对小鼠模型生殖和发育结局的影响。在怀孕前、怀孕期间和哺乳期间，给C57BL/6J雌性小鼠喂食对照饮食（CT）、添加1%或2%表儿茶素和儿茶素混合物的CT饮食（EC1、EC2）或芦丁（RU1、RU2）。在妊娠第18.5天处死一部分母鼠以评估胎儿结局，其余母鼠则让其分娩以评估后代。各组之间母体食物摄入量、体重和组织重量没有差异。吸收、着床数量、窝仔数、出生后存活率、体重和骨骼发育也相似。观察到母体和后代肝脏矿物质浓度的变化。目前的结果表明，在妊娠和哺乳期间摄入大量表儿茶素、儿茶素和芦丁与任何明显的发育影响无关，尽管注意到肝脏矿物质浓度有所变化。
