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华法林与枸杞子（枸杞）之间可能存在相互作用导致出血。

Bleeding due to a probable interaction between warfarin and Gouqizi ( L.).

作者信息

Zhang Jinhua, Tian Lihong, Xie Bixiang

机构信息

Department of Pharmacy, Fujian Medical University Union Hospital, 29 XunQuan Road, Fuzhou 350001, PR China.

Department of nursing, Fujian Medical University Union Hospital, 29 XunQuan Road, Fuzhou 350001, PR China.

出版信息

Toxicol Rep. 2015 Aug 29;2:1209-1212. doi: 10.1016/j.toxrep.2015.08.011. eCollection 2015.

DOI:10.1016/j.toxrep.2015.08.011
PMID:28962463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5598317/
Abstract

Unlike what is widely anticipated by the public, herbal medicines are not always safe despite being natural. We describe a 65-year-old Chinese man taking a prolonged maintenance dose of warfarin who experienced an elevated international normalized ratio (INR) with associated bleeding after drinking Gouqizi (goji berry) wine. This report illustrates that large doses (more than 6-12 g) of Gouqizi can significantly enhance the anticoagulant action of warfarin and may cause similar adverse effects in keeping with three previous reports. Therefore, the use of herbal medicines must adhere to pharmacopoeia-recommended guidelines, including dosage regimes. Doctors should advise patients regarding possible interactions between herbs and warfarin when prescribing and should increase the frequency of INR monitoring for those patients concurrently receiving warfarin and medicinal herbs. Further study is needed to do for the mechanism of interaction between Gouqizi and warfarin.

摘要

与公众的普遍预期不同，草药虽属天然，但并非总是安全的。我们描述了一名65岁的中国男性，他长期服用维持剂量的华法林，在饮用枸杞酒后国际标准化比值（INR）升高并伴有出血。本报告表明，大剂量（超过6 - 12克）的枸杞可显著增强华法林的抗凝作用，并可能导致与之前三份报告类似的不良反应。因此，草药的使用必须遵循药典推荐的指南，包括剂量方案。医生在开处方时应告知患者草药与华法林之间可能存在的相互作用，并应增加对同时服用华法林和草药患者的INR监测频率。需要进一步研究枸杞与华法林之间相互作用的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b0/5598317/ffaf20bcdfe3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b0/5598317/fd52a59bda10/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b0/5598317/ffaf20bcdfe3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b0/5598317/fd52a59bda10/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b0/5598317/ffaf20bcdfe3/gr2.jpg

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