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基于当前文献的选定生物材料和干细胞在儿童牙科硬组织再生中的应用

Application of Selected Biomaterials and Stem Cells in the Regeneration of Hard Dental Tissue in Paediatric Dentistry-Based on the Current Literature.

作者信息

Wrzyszcz-Kowalczyk Alina, Dobrzynski Maciej, Grzesiak-Gasek Iwona, Zakrzewski Wojciech, Mysiak-Debska Monika, Nowak Patrycja, Zimolag Malgorzata, Wiglusz Rafal J

机构信息

Department of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland.

Pre-Clinical Research Centre, Wroclaw Medical University, Bujwida 44, 50-345 Wroclaw, Poland.

出版信息

Nanomaterials (Basel). 2021 Dec 13;11(12):3374. doi: 10.3390/nano11123374.

Abstract

Currently, the development of the use of biomaterials and their application in medicine is causing rapid changes in the fields of regenerative dentistry. Each year, new research studies allow for the discovery of additional possibilities of dental tissue restoration. The structure and functions of teeth are complex. They consist of several diverse tissues that need to act together to ensure the tooth's function and durability. The integrity of a tooth's enamel, dentin, cementum, and pulp tissue allows for successful mastication. Biomaterials that are needed in dentistry must withstand excessive loading forces, be biocompatible with the hosts' tissues, and stable in the oral cavity environment. Moreover, each tooth's tissue, as well as aesthetic qualities in most cases, should closely resemble the natural dental tissues. This is why tissue regeneration in dentistry is such a challenge. This scientific research focuses on paediatric dentistry, its classification of caries, and the use of biomaterials in rebuilding hard dental tissues. There are several methods described in the study, including classical conservative methods such as caries infiltration or stainless-steel crowns. Several clinical cases are present, allowing a reader to better understand the described methods. Although the biomaterials mentioned in this work are artificial, there is currently ongoing research regarding clinical stem cell applications, which have a high potential for becoming one of the most common techniques of lost dental-tissue regeneration in the near future. The current state of stem cell development is mentioned, as well as the various methods of its possible application in dentistry.

摘要

目前,生物材料的开发及其在医学中的应用正在使再生牙科领域发生迅速变化。每年,新的研究都能发现牙齿组织修复的更多可能性。牙齿的结构和功能很复杂。它们由几种不同的组织组成,这些组织需要协同作用以确保牙齿的功能和耐用性。牙齿的釉质、牙本质、牙骨质和牙髓组织的完整性有助于成功咀嚼。牙科所需的生物材料必须承受过大的负荷力,与宿主组织具有生物相容性,并在口腔环境中保持稳定。此外,在大多数情况下,每颗牙齿的组织以及美学品质都应与天然牙齿组织非常相似。这就是为什么牙科中的组织再生是一项如此具有挑战性的任务。这项科学研究聚焦于儿童牙科、龋齿的分类以及生物材料在重建坚硬牙齿组织中的应用。该研究中描述了几种方法,包括龋病渗透或不锈钢冠等经典保守方法。文中呈现了几个临床病例,以便读者更好地理解所描述的方法。尽管这项工作中提到的生物材料是人工的,但目前有关临床干细胞应用的研究正在进行,这些应用在不久的将来极有可能成为缺失牙齿组织再生最常用的技术之一。文中提到了干细胞发展的现状以及其在牙科中可能的各种应用方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bcb/8709498/c7c93b1d67ac/nanomaterials-11-03374-g001.jpg

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