Department of Chemistry, The Scripps Research Institute , La Jolla, California 92037, United States.
ACS Cent Sci. 2016 May 25;2(5):302-8. doi: 10.1021/acscentsci.6b00091. Epub 2016 May 5.
While preparative electrolysis of organic molecules has been an active area of research over the past century, modern synthetic chemists have generally been reluctant to adopt this technology. In fact, electrochemical methods possess many benefits over traditional reagent-based transformations, such as high functional group tolerance, mild conditions, and innate scalability and sustainability. In this Outlook we highlight illustrative examples of electrochemical reactions in the context of the synthesis of complex molecules, showcasing the intrinsic benefits of electrochemical reactions versus traditional reagent-based approaches. Our hope is that this field will soon see widespread adoption in the synthetic community.
虽然过去一个世纪以来,有机分子的制备性电解一直是一个活跃的研究领域,但现代合成化学家通常不愿意采用这种技术。事实上,电化学方法相对于传统的基于试剂的转化方法具有许多优势,例如高官能团耐受性、温和的条件以及内在的可扩展性和可持续性。在这篇观点文章中,我们重点介绍了复杂分子合成背景下电化学反应的说明性实例,展示了电化学反应与传统基于试剂的方法相比的固有优势。我们希望这个领域在合成化学界能很快得到广泛采用。