Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodzki 4a Street, 20- 093 Lublin, Poland.
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Viale Ferdinando Stagno d'Alcontres, 31 98166, S.Agata, Messina, Italy.
Curr Med Chem. 2019;26(27):5152-5164. doi: 10.2174/0929867324666171003114154.
Flavonoids are major dietary constituents of plant-based food found ubiquitously in plant kingdom where they are usually present in substantial amounts. Rutin is a flavonol-type polyphenol which consists of the flavonol quercetin and the disaccharide rutinose. Rutin has been reported to exert diverse biological effects such as antitumor and antimicrobial mainly associated to its antioxidant and anti-inflammatory activities. Mental, neurological, and behavioural disorders are an important and growing cause of morbidity. Most of these disorders combine a high prevalence, early onset, progressive clinical course, and impairment of critical brain functions making them a major contributor to the global disease burden. In the present work, the biological in vitro and in vivo effects and the potential therapeutic applications of rutin in neurodegenerative processes are reviewed, as well as their bioavailability and pharmacokinetics, which are essential for a better understanding of its biological effectiveness. Moreover, the present review also provides an overview of the molecular mechanisms through which rutin is proposed to exert its neuroprotective effects.
类黄酮是植物性食物中的主要膳食成分，广泛存在于植物界，通常含量较高。芦丁是一种黄酮醇型多酚，由黄酮醇槲皮素和二糖芦丁糖组成。芦丁已被报道具有多种生物作用，如抗肿瘤和抗菌作用，主要与其抗氧化和抗炎活性有关。精神、神经和行为障碍是发病率高且不断增长的一个重要原因。这些疾病大多具有高患病率、发病早、进行性临床病程以及对关键大脑功能的损害，使它们成为全球疾病负担的主要原因。在本工作中，综述了芦丁在神经退行性过程中的生物学体外和体内作用及其潜在的治疗应用，以及其生物利用度和药代动力学，这对于更好地理解其生物学有效性是必不可少的。此外，本综述还概述了芦丁发挥其神经保护作用的分子机制。
