Clemens J D, Sack D A, Harris J R, Chakraborty J, Khan M R, Stanton B F, Ali M, Ahmed F, Yunus M, Kay B A
International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Lancet. 1988 Jun 18;1(8599):1375-9. doi: 10.1016/s0140-6736(88)92189-7.
The impact of B subunit killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines was assessed in a randomised double-blind trial in rural Bangladesh. 62,285 children aged 2-15 years and women aged over 15 ingested three doses of one of the vaccines or placebo. During the first year of follow-up there was a 26% reduction of all visits for treatment of diarrhoea in the BS-WC group and a 22% reduction in the WC group. The reduction of all admissions for fatal or severely dehydrating diarrhoea was 48% in the BS-WC group and 33% in the WC group. Overall mortality rates were 26% lower in the BS-WC group and 23% lower in the WC group during the first year, and reductions of mortality were observed only in women vaccinated at ages over 15 years. However, no differences in cumulative mortality were evident at the end of the second year of surveillance.
在孟加拉国农村进行的一项随机双盲试验中，评估了B亚单位灭活全细胞（BS-WC）口服霍乱疫苗和仅灭活全细胞（WC）口服霍乱疫苗的效果。62285名2至15岁的儿童和15岁以上的女性摄入了三剂其中一种疫苗或安慰剂。在随访的第一年，BS-WC组因腹泻接受治疗的所有就诊次数减少了26%，WC组减少了22%。BS-WC组因致命或严重脱水腹泻的所有住院次数减少了48%，WC组减少了33%。在第一年，BS-WC组的总体死亡率降低了26%，WC组降低了23%，且仅在15岁以上接种疫苗的女性中观察到死亡率降低。然而，在监测的第二年结束时，累积死亡率没有明显差异。
