School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX.
Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX.
Schizophr Bull. 2018 Jun 6;44(4):737-748. doi: 10.1093/schbul/sbx117.
Social cognition is increasingly recognized as an important treatment target in schizophrenia; however, the dearth of well-validated measures that are suitable for use in clinical trials remains a significant limitation. The Social Cognition Psychometric Evaluation (SCOPE) study addresses this need by systematically evaluating the psychometric properties of promising measures. In this final phase of SCOPE, eight new or modified tasks were evaluated. Stable outpatients with schizophrenia (n = 218) and healthy controls (n = 154) completed the battery at baseline and 2-4 weeks later across three sites. Tasks included the Bell Lysaker Emotion Recognition Task (BLERT), Penn Emotion Recognition Task (ER-40), Reading the Mind in the Eyes Task (Eyes), The Awareness of Social Inferences Test (TASIT), Hinting Task, Mini Profile of Nonverbal Sensitivity (MiniPONS), Social Attribution Task-Multiple Choice (SAT-MC), and Intentionality Bias Task (IBT). BLERT and ER-40 modifications included response time and confidence ratings. The Eyes task was modified to include definitions of terms and TASIT to include response time. Hinting was scored with more stringent criteria. MiniPONS, SAT-MC, and IBT were new to this phase. Tasks were evaluated on (1) test-retest reliability, (2) utility as a repeated measure, (3) relationship to functional outcome, (4) practicality and tolerability, (5) sensitivity to group differences, and (6) internal consistency. Hinting, BLERT, and ER-40 showed the strongest psychometric properties and are recommended for use in clinical trials. Eyes, TASIT, and IBT showed somewhat weaker psychometric properties and require further study. MiniPONS and SAT-MC showed poorer psychometric properties that suggest caution for their use in clinical trials.
社会认知能力日益被认为是精神分裂症的一个重要治疗靶点；然而，缺乏经过良好验证且适用于临床试验的测量工具仍然是一个重大限制。社会认知心理计量评估（SCOPE）研究通过系统评估有前途的测量工具的心理计量学特性来满足这一需求。在 SCOPE 的最后阶段，评估了 8 种新的或修改的任务。稳定的门诊精神分裂症患者（n=218）和健康对照者（n=154）在三个地点完成了基线和 2-4 周后的测试。任务包括贝尔·莱克萨认知情绪识别任务（BLERT）、宾夕法尼亚情绪识别任务（ER-40）、读心术（Eyes）、社会推理意识测试（TASIT）、暗示任务、非言语敏感性简表（MiniPONS）、社会归因任务多项选择（SAT-MC）和意图偏差任务（IBT）。BLERT 和 ER-40 的修改包括反应时间和置信度评分。Eyes 任务进行了修改，包括术语定义，TASIT 包括反应时间。暗示任务的评分标准更加严格。MiniPONS、SAT-MC 和 IBT 是本阶段的新任务。任务评估的指标有：（1）重测信度，（2）作为重复测量的有效性，（3）与功能结果的关系，（4）实用性和耐受性，（5）对组间差异的敏感性，以及（6）内部一致性。暗示、BLERT 和 ER-40 显示出最强的心理计量学特性，建议用于临床试验。Eyes、TASIT 和 IBT 显示出稍弱的心理计量学特性，需要进一步研究。MiniPONS 和 SAT-MC 显示出较差的心理计量学特性，建议在临床试验中谨慎使用。
