Perng Wei, Rifas-Shiman Sheryl L, Rich-Edwards Janet W, Stuebe Alison M, Oken Emily
a Obesity Prevention Program in the Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute , Boston , MA , USA .
b Connors Center for Women's Health, Brigham and Women's Hospital , Boston , MA , USA , and.
Ann Hum Biol. 2016;43(1):91-5. doi: 10.3109/03014460.2014.968619. Epub 2014 Dec 16.
To investigate whether mid-pregnancy inflammation predicts the rate of subsequent gestational weight gain (GWG) and whether inflammation at 3 years post-partum is associated with weight and waist circumference (WC) gain during a median of 4.4 years follow-up.
This study quantified CRP, IL-6 and TNF-α in plasma of 886 women at ∼28 weeks gestation and calculated GWG rate (kg/week) from blood draw to delivery. At ∼3 years post-partum, CRP and IL-6 were assessed from 351 women and weight and WC were measured at 3 and 7 years post-partum. This study used linear regression to investigate the relationship between mid-pregnancy inflammation and subsequent GWG rate and the association of inflammation at 3 years post-partum with weight and WC change during follow-up.
After accounting for confounders, a small dose-response association of mid-gestation CRP with subsequent GWG was observed; women in the 4th CRP quartile gained weight at 0.05 (95% CI = 0.01, 0.10) kg/week faster than those in the 1st quartile. Neither IL-6 nor TNF-α was related to GWG. Post-partum inflammation was not associated with subsequent weight or WC gain.
Higher mid-gestation CRP was related to modestly higher subsequent GWG rate. Future studies are warranted to confirm these findings.
研究孕中期炎症是否能预测随后的孕期体重增加（GWG）率，以及产后3年的炎症是否与4.4年中位随访期间的体重和腰围（WC）增加有关。
本研究对886名妊娠约28周妇女血浆中的CRP、IL-6和TNF-α进行了定量，并计算了从采血到分娩的GWG率（kg/周）。在产后约3年，对351名妇女进行了CRP和IL-6评估，并在产后3年和7年测量了体重和WC。本研究采用线性回归来研究孕中期炎症与随后的GWG率之间的关系，以及产后3年炎症与随访期间体重和WC变化之间的关联。
在考虑混杂因素后，观察到孕中期CRP与随后的GWG之间存在小剂量反应关联；CRP四分位数第4组的妇女比第1组的妇女每周增重快0.05（95%CI = 0.01，0.10）kg。IL-6和TNF-α均与GWG无关。产后炎症与随后的体重或WC增加无关。
孕中期较高的CRP与随后略高的GWG率有关。未来的研究有必要证实这些发现。
