Machtinger Ronit, Gaskins Audrey J, Mansur Abdallah, Adir Michal, Racowsky Catherine, Baccarelli Andrea A, Hauser Russ, Chavarro Jorge E
Sheba Medical Center, Ramat-Gan and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Fertil Steril. 2017 Dec;108(6):1026-1033. doi: 10.1016/j.fertnstert.2017.09.007. Epub 2017 Oct 3.
To study whether maternal intake of beverage type affects IVF outcomes.
A prospective study.
Tertiary, university-affiliated center.
PATIENT(S): Three hundred forty women undergoing IVF from 2014 through 2016 for infertility as well as for pregenetic diagnosis for autosomal recessive diseases were enrolled during ovarian stimulation and completed a questionnaire describing their usual beverage consumption.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): IVF outcomes were abstracted from medical records. Total caffeine intake was estimated by summing the caffeine content for specific beverages multiplied by frequency of intake. Associations between specific types of beverages and IVF outcomes were analyzed using Poisson and logistic regression models adjusting for possible confounders.
RESULT(S): Higher intake of sugared soda was associated with lower total, mature, and fertilized oocytes and top-quality embryos after ovarian stimulation. Women who consumed sugared soda had, on average, 1.1 fewer oocytes retrieved, 1.2 fewer mature oocytes retrieved, 0.6 fewer fertilized oocytes, and 0.6 fewer top-quality embryos compared with women who did not consume sugared soda. Furthermore, compared with women who did not drink sugared soda, the adjusted difference in percent of cycles resulting in live birth for women consuming 0.1-1 cups/day and >1 cup/day were -12% and -16%, respectively. No associations were found between consumption of coffee, caffeine, or diet sodas and IVF outcome.
CONCLUSION(S): Sugared beverages, independent of their caffeine content, may be a bigger threat to reproductive success than caffeine and caffeinated beverages without added sugar.
研究母亲饮用饮料的类型是否会影响体外受精（IVF）结果。
一项前瞻性研究。
大学附属三级中心。
2014年至2016年期间，340名因不孕以及常染色体隐性疾病进行植入前基因诊断而接受IVF的女性在卵巢刺激期间入组，并完成了一份描述其日常饮料消费情况的问卷。
无。
从病历中提取IVF结果。通过将特定饮料的咖啡因含量乘以摄入频率来估算总咖啡因摄入量。使用泊松回归模型和逻辑回归模型分析特定类型饮料与IVF结果之间的关联，并对可能的混杂因素进行校正。
摄入含糖汽水较多与卵巢刺激后总卵母细胞数、成熟卵母细胞数、受精卵母细胞数及优质胚胎数较低有关。与未饮用含糖汽水的女性相比，饮用含糖汽水的女性平均少取到1.1个卵母细胞、1.2个成熟卵母细胞、0.6个受精卵母细胞和0.6个优质胚胎。此外，与未饮用含糖汽水的女性相比，饮用含糖汽水0.1 - 1杯/天和>1杯/天的女性活产周期百分比的校正差异分别为-12%和-16%。未发现饮用咖啡、咖啡因或无糖汽水与IVF结果之间存在关联。
含糖饮料，无论其咖啡因含量如何，可能比咖啡因和无糖含咖啡因饮料对生殖成功的威胁更大。
