Univ. Estadual Paulista, UNESP, Brazil; Institute of Community Medicine, University of Tromsø, Tromsø, Norway.
Institute of Community Medicine, University of Tromsø, Tromsø, Norway; Norwegian Institute for Air Research, Tromsø, Norway.
Environ Int. 2012 Apr;40:162-169. doi: 10.1016/j.envint.2011.07.006. Epub 2011 Aug 5.
Persistent organic pollutants (POPs) present in the living environment are thought to have detrimental health effects on the population, with pregnant women and the developing foetus being at highest risk. We report on the levels of selected POPs in maternal blood of 155 delivering women residing in seven regions within the São Paulo State, Brazil. The following selected POPs were measured in the maternal whole blood: 12 polychlorinated biphenyls (PCBs) congeners (IUPAC Nos. 99, 101, 118, 138, 153, 156, 163, 170, 180, 183, 187, 194); dichlordiphenyltrichloroethane p,p'-DDT, diphenyldichloroethylene p,p'-DDE and other pesticides such as hexachlorocyclohexanes (α-HCH, β-HCH, γ-HCH), hexachlorobenzene (HCB), chlordane derivatives cis-chlordane, trans-chlordane, oxy-chlordane, cis-nonachlor and trans-nonachlor. Statistical comparisons between regions were performed only on compounds having concentrations above LOD in 70% of the samples. PCB118 congener was found to be highest in the industrial site (mean 4.97 ng/g lipids); PCB138 congener concentration was highest in the Urban 3 site (mean 4.27 ng/g lipids) and congener PCB153 was highest in the industrial and Urban 3 sites with mean concentration of 7.2 ng/g lipids and 5.89ng/g lipids respectively. Large differences in levels of p,p'-DDE between regions were observed with the Urban 3 and industrial sites having the highest concentrations of 645 ng/g lipids and 417 ng/g lipids, respectively; β-HCH was found to be highest in the Rural 1 site; the γ-HCH in Rural 1 and industrial; the HCB in the Rural 1 and industrial sites and oxy-chlordane and t-NC in the Rural 2 sites. An association between levels of some contaminants and maternal age and parity was also found.
居住环境中的持久性有机污染物 (POPs) 被认为对人口健康有不利影响，孕妇和发育中的胎儿风险最高。我们报告了巴西圣保罗州 7 个地区 155 名分娩妇女的母体血液中选定的 POPs 水平。在母体全血中测量了以下选定的 POPs：12 种多氯联苯 (PCB) 同系物（IUPAC 编号 99、101、118、138、153、156、163、170、180、183、187、194）；二氯二苯三氯乙烷 p,p'-DDT、二氯二苯二氯乙烯 p,p'-DDE 以及其他农药，如六氯环己烷（α-HCH、β-HCH、γ-HCH）、六氯苯 (HCB)、氯丹衍生物顺式氯丹、反式氯丹、氧氯丹、顺式-十氯酮和反式-十氯酮。仅对在 70%的样本中浓度高于检出限的化合物在区域之间进行了统计比较。在工业点发现 PCB118 同系物含量最高（平均 4.97ng/g 脂质）；在城市 3 点发现 PCB138 同系物浓度最高（平均 4.27ng/g 脂质），在工业和城市 3 点发现 PCB153 同系物浓度最高，平均浓度分别为 7.2ng/g 脂质和 5.89ng/g 脂质。在区域之间观察到 p,p'-DDE 的水平存在很大差异，城市 3 点和工业点的浓度分别为 645ng/g 脂质和 417ng/g 脂质；在农村 1 点发现 β-HCH 含量最高；γ-HCH 在农村 1 点和工业点；HCB 在农村 1 点和工业点；氧氯丹和 t-NC 在农村 2 点。还发现一些污染物的水平与母亲的年龄和胎次有关。
