Lally Michelle A, van den Berg Jacob J, Westfall Andrew O, Rudy Bret J, Hosek Sybil G, Fortenberry J Dennis, Monte Dina, Tanney Mary R, McFarland Elizabeth J, Xu Jiahong, Kapogiannis Bill G, Wilson Craig M
Department of Medicine, Lifespan Hospital Systems, Alpert Medical School of Brown University, VA Medical Center, Providence, RI.
Department of Behavioral and Social Sciences, Center for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI.
J Acquir Immune Defic Syndr. 2018 Jan 1;77(1):110-117. doi: 10.1097/QAI.0000000000001563.
Beneficial HIV treatment outcomes require success at multiple steps along the HIV Continuum of Care. Youth living with HIV are a key population, and sites in the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) are known for modeling optimum HIV adolescent care.
A longitudinal cohort study conducted at 14 network sites across the United States assessed how the later steps of the Continuum of Care were achieved among the youth: engagement, treatment, and viral load (VL) suppression. Youth aged 13-24 who were behaviorally infected with HIV and linked to care at an ATN-affiliated site were eligible to participate.
A total of 467 youth were enrolled and had 1 year of available data. Most were aged 22-24 (57%), male (79%), and black/non-Hispanic (71%). Most used alcohol (81%) and marijuana (61%) in the 3 months before enrollment, and 40% had a history of incarceration. Among this cohort of youth, 86% met criteria for care engagement; among these, 98% were prescribed antiretroviral therapy and 89% achieved VL suppression. Sustained VL suppression at all measured time points was found among 59% with initial suppression. Site characteristics were notable for the prevalence of adherence counseling (100%), case management (100%), clinic-based mental health (93%), and substance use (64%) treatment.
Youth living with HIV in the United States can be successfully treated at health care sites with experience, excellence, and important resources and services. Sustained VL suppression may be an important step to add to the Continuum of Care for youth.
有效的HIV治疗结果需要在HIV连续护理的多个步骤中取得成功。感染HIV的青少年是关键人群,而青少年医学艾滋病干预试验网络(ATN)的各站点以树立最佳的HIV青少年护理典范而闻名。
在美国14个网络站点进行的一项纵向队列研究,评估了青少年在连续护理的后续步骤中是如何实现的:参与、治疗和病毒载量(VL)抑制。13至24岁、因行为感染HIV并在ATN附属站点接受护理的青少年有资格参与。
共招募了467名青少年,并有1年的可用数据。大多数人年龄在22 - 24岁(57%),男性(79%),黑人/非西班牙裔(71%)。大多数人在入组前3个月使用过酒精(81%)和大麻(61%),40%有监禁史。在这一队列的青少年中,86%符合护理参与标准;其中,98%被开具抗逆转录病毒疗法,89%实现了病毒载量抑制。在最初实现抑制的人群中,59%在所有测量时间点都保持了病毒载量抑制。各站点的特点是坚持咨询(100%)、病例管理(100%)、基于诊所的心理健康(93%)和物质使用(64%)治疗的普及率较高。
在美国,感染HIV的青少年可以在具备经验、卓越水平以及重要资源和服务的医疗保健站点得到成功治疗。持续的病毒载量抑制可能是青少年连续护理中需要增加的重要一步。