Liu Zhi, Pericak-Vance Margaret A, Goldschmidt-Clermont Pascal, Seo David, Wang Liyong, Rundek Tatjana, Beecham Gary W
John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America.
Division of Cardiology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.
PLoS One. 2017 Oct 10;12(10):e0183836. doi: 10.1371/journal.pone.0183836. eCollection 2017.
Coronary collateral circulation protects cardiac tissues from myocardial infarction damage and decreases sudden cardiac death. So far, it is unclear how coronary collateralization varies by race-ethnicity groups and by sex.
We assessed 868 patients with obstructive CAD. Patients were assessed for collateral grades based on Rentrop grading system, as well as other covariates. DNA samples were genotyped using the Affymetrix 6.0 genotyping array. To evaluate genetic contributions to collaterals, we performed admixture mapping using logistic regression with estimated local and global ancestry.
Overall, 53% of participants had collaterals. We found difference between sex and racial-ethnic groups. Men had higher rates of collaterals than women (P-value = 0.000175). White Hispanics/Latinos showed overall higher rates of collaterals than African Americans and non-Hispanic Whites (59%, 50% and 48%, respectively, P-value = 0.017), and especially higher rates in grade 1 and grade 3 collateralization than the other two populations (P-value = 0.0257). Admixture mapping showed Native American ancestry was associated with the presence of collaterals at a region on chromosome 17 (chr17:35,243,142-41,251,931, β = 0.55, P-value = 0.000127). African ancestry also showed association with collaterals at a different region on chromosome 17 (chr17: 32,266,966-34,463,323, β = 0.38, P-value = 0.00072).
In our study, collateralization showed sex and racial-ethnic differences in obstructive CAD patients. We identified two regions on chromosome 17 that were likely to harbor genetic variations that influenced collateralization.
冠状动脉侧支循环可保护心脏组织免受心肌梗死损伤，并降低心源性猝死风险。目前尚不清楚冠状动脉侧支循环在不同种族和性别群体中如何变化。
我们评估了868例阻塞性冠心病患者。根据Rentrop分级系统以及其他协变量对患者的侧支等级进行评估。使用Affymetrix 6.0基因分型阵列对DNA样本进行基因分型。为了评估基因对侧支循环的影响，我们使用逻辑回归和估计的局部和全局祖先进行混合映射。
总体而言，53%的参与者有侧支循环。我们发现性别和种族群体之间存在差异。男性的侧支循环发生率高于女性（P值=0.000175）。西班牙裔/拉丁裔白人的侧支循环总体发生率高于非裔美国人和非西班牙裔白人（分别为59%、50%和48%，P值=0.017），尤其是1级和3级侧支循环发生率高于其他两个人群（P值=0.0257）。混合映射显示，美洲原住民血统与17号染色体上一个区域的侧支循环存在相关（chr17:35,243,142 - 41,251,931，β = 0.55，P值=0.000127）。非洲血统在17号染色体的另一个不同区域也显示与侧支循环相关（chr17: 32,266,966 - 34,463,323，β = 0.38，P值=0.00072）。
在我们的研究中，阻塞性冠心病患者的侧支循环存在性别和种族差异。我们在17号染色体上确定了两个区域，可能存在影响侧支循环的基因变异。
