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甲型 H5N1 流感病毒感染致脑炎并并发梗阻性脑积水 1 例

Influenza A(H5N1) Virus Infection in a Child With Encephalitis Complicated by Obstructive Hydrocephalus.

机构信息

Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, University of Hong Kong.

HKU-Pasteur Research Pole, School of Public Health, University of Hong Kong.

出版信息

Clin Infect Dis. 2018 Jan 6;66(1):136-139. doi: 10.1093/cid/cix707.

DOI:10.1093/cid/cix707
PMID:29020163
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5850530/
Abstract

A 2-year-old boy with highly pathogenic avian influenza A(H5N1) virus infection with minimal respiratory symptoms developed encephalitis complicated by obstructive hydrocephalus. Viral RNA was detectable in cerebrospinal fluid. The virus belonged to H5N1 clade 2.3.2.1b and had acquired the mammalian adaptation mutation PB2 Q591K.

摘要

一名 2 岁男童感染高致病性禽流感 A(H5N1)病毒，症状轻微，但出现了伴有阻塞性脑积水的脑炎。病毒 RNA 可在脑脊液中检测到。该病毒属于 H5N1 分支 2.3.2.1b，且获得了哺乳动物适应突变 PB2 Q591K。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dca/5850530/42be47a4ede1/cix70701.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dca/5850530/42be47a4ede1/cix70701.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dca/5850530/42be47a4ede1/cix70701.jpg

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