Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine.
Proc Jpn Acad Ser B Phys Biol Sci. 2017;93(8):600-608. doi: 10.2183/pjab.93.038.
Molecules involved in the disease process facilitated our understanding of pathogenesis of the disease with unknown etiology such as immune-mediated and inflammatory diseases. Moreover, the targeted therapies against the proposed molecular targets by biological agents provide enormous benefits to the patients and societies. Here, I will review recent progress of the biological treatment in the immune-inflammatory diseases by focusing on the rheumatoid arthritis, the disease characterized by persistent polyarthritis leading to joint destruction and disability with autoimmune features, as a role model.
参与疾病过程的分子使我们能够理解病因不明的疾病的发病机制，如免疫介导和炎症性疾病。此外，生物制剂针对提出的分子靶点的靶向治疗为患者和社会带来了巨大的益处。在这里，我将以类风湿关节炎为模型，重点介绍具有自身免疫特征的持续性多关节炎导致关节破坏和残疾的疾病，综述免疫炎症性疾病的生物治疗的最新进展。
