College of Chemistry, Jilin University , Changchun 130012, China.
Department of Physiology, College of Basic Medical Sciences, Jilin University , Changchun 130021, China.
ACS Appl Mater Interfaces. 2017 Nov 1;9(43):37991-37999. doi: 10.1021/acsami.7b14029. Epub 2017 Oct 19.
In this paper, a new class of metal-free nanocarbon catalyst-nitrogen (N) and sulfur (S) codoped graphene quantum dot/graphene (NS-GQD/G) hybrid nanosheets-was designed and synthesized for sensitive detection of hydrogen peroxide (HO). NS-GQD/G was prepared through two steps. First, graphene quantum dots (GQDs) were self-assembled on graphene nanoplatelets via hydrothermal treatment to constitute hybrid nanosheets, followed by a thermal annealing procedure using the hybrid nanosheets and thiourea to form the NS-GQD/G hybrid nanosheets. This hybrid material possessed high specific surface area, numerous doping sites and edges, and high electrical conductivity, which leads to ultrahigh performance toward HO electrocatalysis reduction. Under the optimal experimental conditions, the proposed HO sensor displayed an extended linear response in the range from 0.4 μM to 33 mM with a low detection limit of 26 nM (S/N = 3). In addition to desirable selectivity, ideal reproducibility, and long-time stability, this HO sensor exhibited desirable performance in detecting HO in the human serum samples and that released from Raw 264.7 cells. Therefore, the novel NS-GQD/G nanocomposite was a promising metal-free material in the fields of electrochemical sensing and bioanalysis.
本文设计并合成了一种新型的无金属纳米碳催化剂——氮（N）和硫（S）共掺杂石墨烯量子点/石墨烯（NS-GQD/G）杂化纳米片，用于灵敏检测过氧化氢（HO）。NS-GQD/G 通过两步法制备得到。首先，通过水热处理使石墨烯量子点（GQDs）自组装在石墨烯纳米片上，构成杂化纳米片，然后使用该杂化纳米片和硫脲进行热退火处理，形成 NS-GQD/G 杂化纳米片。这种杂化材料具有高比表面积、丰富的掺杂位和边缘以及高导电性，这使其对 HO 电催化还原具有超高的性能。在最佳实验条件下，所提出的 HO 传感器在 0.4 μM 至 33 mM 的范围内呈现出扩展的线性响应，检测限低至 26 nM（S/N = 3）。除了具有良好的选择性、理想的重现性和长时间稳定性外，该 HO 传感器在检测人血清样品和 Raw 264.7 细胞释放的 HO 方面表现出了良好的性能。因此，新型 NS-GQD/G 纳米复合材料是电化学传感和生物分析领域中一种很有前途的无金属材料。
