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用于植入式膀胱压力监测设备的可调谐、轻量化片上事件检测。

Tunable and Lightweight On-Chip Event Detection for Implantable Bladder Pressure Monitoring Devices.

出版信息

IEEE Trans Biomed Circuits Syst. 2017 Dec;11(6):1303-1312. doi: 10.1109/TBCAS.2017.2748981. Epub 2017 Oct 11.

Abstract

Lower urinary tract dysfunctions, such as urinary incontinence and overactive bladder, are conditions that greatly affect the quality of life for millions of individuals worldwide. For those with more complex pathophysiologies, diagnosis of these conditions often requires a urodynamics study, providing physicians with a snapshot view of bladder mechanics. Recent advancements in implantable bladder pressure monitors and advanced data analysis techniques have made diagnosis through chronic monitoring a promising prospect. However, implants targeted at treatment must remain in the bladder for long periods of time, making minimizing power consumption a primary design objective. Currently, much of the typical implant's power draw is due to data transmission. Previous work has demonstrated an adaptive rate transmission technique to reduce power consumption. However, the ultimate reduction in power consumption can only be attained when the device does not transmit bladder pressure samples, but rather bladder events. In this paper, we present an algorithm and circuit level implementation for on-chip bladder pressure data compression and event detection. It is designed to be a complete, tunable, and lightweight diagnosis and treatment framework for bladder pressure monitoring implants, capable of selectively transmitting compressed bladder pressure data with tunable quality, "snapshots" of significant bladder events, or simply indicate events occurred for the highest energy efficiency. The design aims to minimize area through resource reuse, leading to a total area of 1.75 , and employs advanced VLSI techniques for power reduction. With compression and event detection enabled, the design consumes roughly 2.6 nW in TSMC technology. With only event detection, this reduces to 2.1 nW, making this approach ideal for long-life implantable bladder pressure monitoring devices.

摘要

下尿路功能障碍,如尿失禁和膀胱过度活动症,是影响全球数百万人生活质量的病症。对于那些具有更复杂病理生理学的患者,这些病症的诊断通常需要进行尿动力学研究,为医生提供膀胱力学的实时视图。最近,可植入膀胱压力监测器和先进数据分析技术的进步使得通过慢性监测进行诊断成为一个有前途的前景。然而,用于治疗的植入物必须在膀胱中停留很长时间,因此最大限度地降低功耗成为主要设计目标。目前,大部分典型植入物的功耗都来自于数据传输。以前的工作已经展示了一种自适应速率传输技术来降低功耗。然而,只有当设备不传输膀胱压力样本,而是传输膀胱事件时,才能实现最终的功耗降低。在本文中,我们提出了一种用于片上膀胱压力数据压缩和事件检测的算法和电路级实现。它旨在成为一种完整、可调节、轻量级的膀胱压力监测植入物诊断和治疗框架,能够选择性地以可调节质量传输压缩的膀胱压力数据、膀胱事件的“快照”,或者只是为了最高的能量效率而指示事件发生。该设计旨在通过资源复用来最小化面积,总面积为 1.75 ,并采用先进的 VLSI 技术来降低功耗。启用压缩和事件检测时,该设计在 TSMC 技术下消耗大约 2.6 nW 的功率。仅启用事件检测时,这将降低到 2.1 nW,因此这种方法非常适合用于具有长寿命的可植入膀胱压力监测设备。

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本文引用的文献

1
Wireless Implantable Pressure Monitor for Conditional Bladder Neuromodulation.用于条件性膀胱神经调节的无线植入式压力监测器
IEEE Biomed Circuits Syst Conf. 2015 Oct;2015. doi: 10.1109/biocas.2015.7348337. Epub 2015 Dec 7.
3
Suburothelial Bladder Contraction Detection with Implanted Pressure Sensor.植入式压力传感器检测膀胱黏膜下层收缩
PLoS One. 2017 Jan 6;12(1):e0168375. doi: 10.1371/journal.pone.0168375. eCollection 2017.
9
Estimation of bladder volume from afferent neural activity.从传入神经活动估算膀胱容量。
IEEE Trans Neural Syst Rehabil Eng. 2013 Sep;21(5):704-15. doi: 10.1109/TNSRE.2013.2266899. Epub 2013 Jun 10.
10
A system for long-term urodynamic studies without catheters.一种无需导管的长期尿动力学研究系统。
Eur Urol. 2013 May;63(5):966-8. doi: 10.1016/j.eururo.2013.01.029. Epub 2013 Feb 4.

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