Craig Jean V, Bunn Diane K, Hayhoe Richard P, Appleyard Will O, Lenaghan Elizabeth A, Welch Ailsa A
Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
Nutr Rev. 2017 Oct 1;75(10):830-857. doi: 10.1093/nutrit/nux042.
An understanding of the modifiable effects of diet on bone and skeletal muscle mass and strength over the life course will help inform strategies to reduce age-related fracture risk. The Mediterranean diet is rich in nutrients that may be important for optimal musculoskeletal health. The aim of this systematic review was to investigate the relationship between a Mediterranean diet and musculoskeletal outcomes (fracture, bone density, osteoporosis, sarcopenia) in any age group. Ten electronic databases were searched. Randomized controlled trials and prospective cohort studies that investigated a traditional Mediterranean diet, published in any language, were eligible. Studies using other designs or other definitions of the Mediterranean diet were collated separately in an evidence map. Details on study design, methods, population, dietary intervention or exposure, length of follow-up, and effect on or association with musculoskeletal outcomes were extracted. The search yielded 1738 references. Data from eligible randomized controlled trials (n = 0) and prospective cohort studies (n = 3) were synthesized narratively by outcome for the systematic review. Two of these studies reported on hip fracture incidence, but results were contradictory. A third study found no association between the Mediterranean diet and sarcopenia incidence. Overall, the systematic review and evidence map demonstrate a lack of research to understand the relationship between the Mediterranean diet and musculoskeletal health in all ages. PROSPERO registration number IDCRD42016037038.
了解饮食在整个生命过程中对骨骼和骨骼肌质量及强度的可改变影响，将有助于制定降低与年龄相关骨折风险的策略。地中海饮食富含对最佳肌肉骨骼健康可能很重要的营养物质。本系统评价的目的是调查地中海饮食与任何年龄组的肌肉骨骼结局（骨折、骨密度、骨质疏松症、肌肉减少症）之间的关系。检索了10个电子数据库。纳入以任何语言发表的、研究传统地中海饮食的随机对照试验和前瞻性队列研究。使用其他设计或地中海饮食其他定义的研究在证据图中单独整理。提取了关于研究设计、方法、人群、饮食干预或暴露、随访时间以及对肌肉骨骼结局的影响或关联的详细信息。检索共获得1738篇参考文献。对符合条件的随机对照试验（n = 0）和前瞻性队列研究（n = 3）的数据按结局进行叙述性综合，以进行系统评价。其中两项研究报告了髋部骨折发生率，但结果相互矛盾。第三项研究发现地中海饮食与肌肉减少症发生率之间无关联。总体而言，系统评价和证据图表明缺乏研究来了解地中海饮食与所有年龄段肌肉骨骼健康之间的关系。国际前瞻性系统评价注册库注册号：IDCRD42016037038。
