微生物易位：将猴免疫缺陷病毒转化为人免疫缺陷病毒。
Microbial translocation: translating simian immunodeficiency virus to HIV.
机构信息
Laboratory of Parasitology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
出版信息
Curr Opin HIV AIDS. 2018 Jan;13(1):15-21. doi: 10.1097/COH.0000000000000424.
Abstract
PURPOSE OF REVIEW
The article describes recent advances in understanding the causes and consequences of microbial translocation in HIV and simian immunodeficiency virus infections.
RECENT FINDINGS
Persistent microbial translocation contributes to aberrant immune activation in immunodeficiency lentiviral infections and thereby, pathogenesis and mortality. Efforts to delineate the circumstances surrounding translocation have benefited from use of simian immunodeficiency virus-infected nonhuman primates and highlight the overwhelming immunologic diversion caused by translocating microbes. The use of therapeutics aimed at reducing microbial translocation show promise and will benefit from continued research into the mechanisms that promote systemic microbial dissemination in treated and untreated infections.
SUMMARY
Insights into the source and identity of translocating microbes in lentiviral infections continue to enhance the development of adjunct therapeutics.
摘要
目的综述
本文描述了在理解 HIV 和猴免疫缺陷病毒感染中微生物易位的原因和后果方面的最新进展。
最近的发现
持续的微生物易位导致免疫缺陷性慢病毒感染中的异常免疫激活，从而导致发病机制和死亡率。为了描述易位的情况，使用感染猴免疫缺陷病毒的非人类灵长类动物进行了研究，并强调了易位微生物引起的压倒性免疫转移。旨在减少微生物易位的治疗方法的应用具有广阔的前景，并将受益于对促进治疗和未治疗感染中全身微生物传播的机制的持续研究。
总结
对慢病毒感染中易位微生物的来源和特性的深入了解，继续促进辅助治疗方法的发展。
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