He Xing-Kang, Lin Zheng-Hua, Qian Yun, Xia Daheng, Jin Piaopiao, Sun Lei-Min
Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University Medical School, Hangzhou, China.
Institute of Gastroenterology, Zhejiang University (IGZJU), Hangzhou, China.
Oncotarget. 2016 Aug 5;8(39):64954-64963. doi: 10.18632/oncotarget.11066. eCollection 2017 Sep 12.
Marital status is viewed as an independent prognostic factor for survival in various cancer types. However, its role in primary liver cancer has yet to be thoroughly explored.
To investigate the impact of marital status on survival outcomes among liver cancer patients.
We finally identified 40,809 eligible liver cancer patients between 2004 and 2012, including 21,939 (53.8%) patients were married at diagnosis and 18,870 (46.2%) were unmarried (including 5,871 divorced/separated, 4,338 widowed and 8,660 single). Married patients enjoyed overall and cause-specific survival outcomes compared with patients who were divorced/separated, widowed, single, respectively. The survival benefit associated with marriage still persisted even after adjusted for known confounders. Widowed individuals were at greater risk of overall and cancer-specific mortality compared to other groups. Similar associations were observed in subgroup analyses according to SEER stage.
We used the Surveillance, Epidemiology and End Results (SEER) database to identify 40,809 patients diagnosed with primary liver cancer between 2004 and 2012. Kaplan-Meier analysis and Cox regression were performed to identify the influence of marital status on overall survival (OS) and liver cancer-specific survival (CSS).
In primary liver cancer patients, married patients enjoyed survival benefits while widowed persons suffered survival disadvantages in both overall survival and cancer-specific survival.
婚姻状况被视为多种癌症类型生存的独立预后因素。然而，其在原发性肝癌中的作用尚未得到充分探讨。
研究婚姻状况对肝癌患者生存结局的影响。
我们最终确定了2004年至2012年间40809例符合条件的肝癌患者，其中21939例（53.8%）在诊断时已婚，18870例（46.2%）未婚（包括5871例离婚/分居、4338例丧偶和8660例单身）。与离婚/分居、丧偶、单身患者相比，已婚患者的总生存期和病因特异性生存期更佳。即使在对已知混杂因素进行调整后，与婚姻相关的生存益处仍然存在。与其他组相比，丧偶个体的总死亡率和癌症特异性死亡率风险更高。根据监测、流行病学和最终结果（SEER）分期进行的亚组分析中也观察到了类似的关联。
我们使用SEER数据库确定了2004年至2012年间40809例诊断为原发性肝癌的患者。进行了Kaplan-Meier分析和Cox回归，以确定婚姻状况对总生存期（OS）和肝癌特异性生存期（CSS）的影响。
在原发性肝癌患者中，已婚患者在总生存期和癌症特异性生存期方面享有生存益处，而丧偶者则面临生存劣势。
