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长链非编码RNA TUG1通过调控miR-138-5p-SIRT1轴促进宫颈癌进展。

Long non-coding RNA TUG1 promotes cervical cancer progression by regulating the miR-138-5p-SIRT1 axis.

作者信息

Zhu Jie, Shi Huirong, Liu Huina, Wang Xiaojuan, Li Fengmei

机构信息

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.

Department of Obstetrics and Gynecology, Zhengzhou Central Hospital, Zhengzhou 450000, Henan, China.

出版信息

Oncotarget. 2017 May 26;8(39):65253-65264. doi: 10.18632/oncotarget.18224. eCollection 2017 Sep 12.

DOI:10.18632/oncotarget.18224
PMID:29029428
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5630328/
Abstract

Increasing evidences showed that long non-coding RNAs (lncRNAs) play vital roles in tumor progression. Recent studies indicated that lncRNA TUG1 was upregulated and promoted tumor processes in several cancers. However, the expression and underlying mechanism of TUG1 in cervical cancer remain unclear. In the present study, we found that TUG1 expression was upregulated in cervical cancer tissues and correlated with advanced clinical features and poor overall survival. TUG1 knockdown suppressed cervical cancer cell growth and metastasis and tumor growth . In addition, our results indicated that TUG1 could act as an endogenous sponge by directly binding to miR-138-5p and suppressed miR-138-5p expression. Furthermore, we found that TUG1 could reverse the inhibitory effect of miR-138-5p on cervical cancer cells processes, which might be involved in the activation of SIRT1, a target gene of miR-138-5p, and activation of Wnt/β-catenin signaling pathway. Taken together, we elucidated that TUG1 might promote cervical cancer malignant progression via miR-138-5p-SIRT1-Wnt/β-catenin signaling pathway axis.

摘要

越来越多的证据表明，长链非编码RNA（lncRNAs）在肿瘤进展中起着至关重要的作用。最近的研究表明，lncRNA TUG1在几种癌症中表达上调并促进肿瘤进程。然而，TUG1在宫颈癌中的表达及潜在机制仍不清楚。在本研究中，我们发现TUG1在宫颈癌组织中表达上调，且与晚期临床特征及较差的总生存率相关。敲低TUG1可抑制宫颈癌细胞的生长、转移及肿瘤生长。此外，我们的结果表明，TUG1可通过直接结合miR-138-5p作为内源性海绵，并抑制miR-138-5p的表达。此外，我们发现TUG1可逆转miR-138-5p对宫颈癌细胞进程的抑制作用，这可能与miR-138-5p的靶基因SIRT1的激活以及Wnt/β-连环蛋白信号通路的激活有关。综上所述，我们阐明了TUG1可能通过miR-138-5p-SIRT1-Wnt/β-连环蛋白信号通路轴促进宫颈癌的恶性进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/dceaa0c8f26e/oncotarget-08-65253-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/d99d86ec7f71/oncotarget-08-65253-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/f170f978d2e8/oncotarget-08-65253-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/c2c6a4684617/oncotarget-08-65253-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/c08edbf8b821/oncotarget-08-65253-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/50ab57f77bca/oncotarget-08-65253-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/83bae2dcf986/oncotarget-08-65253-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/0f489e7a821b/oncotarget-08-65253-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/dceaa0c8f26e/oncotarget-08-65253-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/d99d86ec7f71/oncotarget-08-65253-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/f170f978d2e8/oncotarget-08-65253-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/c2c6a4684617/oncotarget-08-65253-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/c08edbf8b821/oncotarget-08-65253-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/50ab57f77bca/oncotarget-08-65253-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/83bae2dcf986/oncotarget-08-65253-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/0f489e7a821b/oncotarget-08-65253-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5455/5630328/dceaa0c8f26e/oncotarget-08-65253-g008.jpg

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