Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, 75 Bokjiro, Busan Jin-Gu, Busan, 47392, South Korea.
Int Arch Occup Environ Health. 2018 Feb;91(2):185-193. doi: 10.1007/s00420-017-1269-0. Epub 2017 Oct 13.
We assessed the association of blood mercury concentration with metabolic and weight phenotypes.
Blood mercury concentration, metabolic syndrome components, and body mass index (BMI) were measured in 6006 Korean adults (2963 men, 3043 women, mean age 44.7 ± 14.7 years), using the 2011-2013 Korean National Health and Nutrition Examination Survey data. Metabolic and weight phenotypes were classified based on BMI and metabolic syndrome (MetS) presence as metabolically healthy and normal weight (MHNW), metabolically unhealthy and normal weight (MUNW), metabolically healthy and obese (MHO), and metabolically unhealthy and obese (MUO).
The geometric mean of blood mercury concentration was 3.37 μg/L (95% CI 3.32-3.43). A higher quartile of blood mercury concentration was associated with older age, male sex, higher education, alcohol use, current smoking, low physical activity, greater energy intake, and hypertension history. After adjusting for confounding factors (age, sex, education, income, health behaviors, and energy intake), blood mercury concentration tended to increase across the MHNW, MUNW, MHO, and MUO groups in all subjects and each sex (P for trend < 0.01). Compared to the lowest mercury quartile group, adjusted odds ratios (95% CI) for MHO and MUO in those with the highest mercury quartile were, respectively, 1.67 (1.34, 2.09) and 2.02 (1.59, 2.56) in all subjects: 1.58 (1.25, 1.99) and 1.72 (1.37, 2.16) for men; 1.33 (0.94, 1.88) and 1.90 (1.34, 2.70) for women.
Blood mercury concentration was associated with both metabolic syndrome and obesity, and the association was dose dependent across metabolic and weight phenotypes.
评估血液汞浓度与代谢和体重表型的关系。
利用 2011-2013 年韩国国家健康和营养调查数据，对 6006 名韩国成年人（男 2963 名，女 3043 名，平均年龄 44.7±14.7 岁）的血液汞浓度、代谢综合征成分和体重指数（BMI）进行了测量。根据 BMI 和代谢综合征（MetS）的存在，将代谢和体重表型分为代谢健康和正常体重（MHNW）、代谢不健康和正常体重（MUNW）、代谢健康和肥胖（MHO）以及代谢不健康和肥胖（MUO）。
血液汞浓度的几何平均值为 3.37μg/L（95%CI 3.32-3.43）。血液汞浓度较高的四分位数与年龄较大、男性、较高的教育程度、饮酒、当前吸烟、体力活动较少、能量摄入较多以及高血压病史有关。在调整了混杂因素（年龄、性别、教育程度、收入、健康行为和能量摄入）后，在所有受试者和各性别中，血液汞浓度在 MHNW、MUNW、MHO 和 MUO 组中均呈上升趋势（趋势检验 P<0.01）。与最低汞四分位数组相比，在所有受试者中，最高汞四分位数组 MHO 和 MUO 的调整比值比（95%CI）分别为 1.67（1.34，2.09）和 2.02（1.59，2.56）：男性分别为 1.58（1.25，1.99）和 1.72（1.37，2.16）；女性分别为 1.33（0.94，1.88）和 1.90（1.34，2.70）。
血液汞浓度与代谢综合征和肥胖均有关，且与代谢和体重表型呈剂量依赖性关系。
