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在住院的沙特成年患者中,流感比中东呼吸综合征冠状病毒(MERS-CoV)更为常见。

Influenza is more common than Middle East Respiratory Syndrome Coronavirus (MERS-CoV) among hospitalized adult Saudi patients.

机构信息

Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Indiana University School of Medicine, Indianapolis, IN, USA.

Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.

出版信息

Travel Med Infect Dis. 2017 Nov-Dec;20:56-60. doi: 10.1016/j.tmaid.2017.10.004. Epub 2017 Oct 12.

Abstract

BACKGROUND

Since the initial description of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), we adopted a systematic process of screening patients admitted with community acquired pneumonia. Here, we report the result of the surveillance activity in a general hospital in Saudi Arabia over a four year period.

MATERIALS AND METHODS

All admitted patients with community acquired pneumonia from 2012 to 2016 were tested for MERS-CoV. In addition, testing for influenza viruses was carried out starting April 2015.

RESULTS

During the study period, a total of 2657 patients were screened for MERS-CoV and only 20 (0.74%) tested positive. From January 2015 to December 2016, a total of 1644 patients were tested for both MERS-CoV and influenza. None of the patients tested positive for MERS-CoV and 271 (16.4%) were positive for influenza. The detected influenza viruses were Influenza A (107, 6.5%), pandemic 2009 H1N1 (n = 120, 7.3%), and Influenza B (n = 44, 2.7%). Pandemic H1N1 was the most common influenza in 2015 with a peak in peaked October to December and influenza A other than H1N1 was more common in 2016 with a peak in August and then October to December.

CONCLUSIONS

MERS-CoV was a rare cause of community acquired pneumonia and other viral causes including influenza were much more common. Thus, admitted patients are potentially manageable with Oseltamivir or Zanamivir therapy.

摘要

背景

自中东呼吸综合征冠状病毒(MERS-CoV)首次描述以来,我们采用了系统的程序来筛选因社区获得性肺炎而入院的患者。在这里,我们报告了在沙特阿拉伯的一家综合医院进行的为期四年的监测活动的结果。

材料和方法

从 2012 年到 2016 年,所有因社区获得性肺炎入院的患者都接受了 MERS-CoV 检测。此外,从 2015 年 4 月开始,还对流感病毒进行了检测。

结果

在研究期间,共对 2657 名患者进行了 MERS-CoV 筛查,只有 20 名(0.74%)检测结果为阳性。从 2015 年 1 月至 2016 年 12 月,共有 1644 名患者同时接受了 MERS-CoV 和流感检测。没有患者 MERS-CoV 检测呈阳性,271 名(16.4%)患者流感检测呈阳性。检测到的流感病毒为甲型流感(107 例,6.5%)、大流行 2009 年 H1N1(n=120,7.3%)和乙型流感(n=44,2.7%)。大流行 H1N1 是 2015 年最常见的流感病毒,高峰期在 10 月至 12 月,甲型流感(H1N1 以外)在 2016 年更为常见,高峰期在 8 月和 10 月至 12 月。

结论

MERS-CoV 是社区获得性肺炎的罕见病因,而其他病毒病因,包括流感,更为常见。因此,入院患者可通过奥司他韦或扎那米韦治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ad/7110697/ef312a521b2c/gr1_lrg.jpg

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