Snow Michoel, Coen-Cagli Ruben, Schwartz Odelia
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
F1000Res. 2017 Jul 27;6:1246. doi: 10.12688/f1000research.11154.1. eCollection 2017.
The perception of, and neural responses to, sensory stimuli in the present are influenced by what has been observed in the past-a phenomenon known as adaptation. We focus on adaptation in visual cortical neurons as a paradigmatic example. We review recent work that represents two shifts in the way we study adaptation, namely (i) going beyond single neurons to study adaptation in populations of neurons and (ii) going beyond simple stimuli to study adaptation to natural stimuli. We suggest that efforts in these two directions, through a closer integration of experimental and modeling approaches, will enable a more complete understanding of cortical processing in natural environments.
当下对感觉刺激的感知以及神经反应会受到过去所观察到的情况的影响——这一现象被称为适应性。我们将视觉皮层神经元中的适应性作为一个典型例子来关注。我们回顾了近期的研究工作，这些工作代表了我们研究适应性方式的两个转变，即（i）从单个神经元扩展到研究神经元群体中的适应性，以及（ii）从简单刺激扩展到研究对自然刺激的适应性。我们认为，通过更紧密地整合实验和建模方法，在这两个方向上的努力将使我们能更全面地理解自然环境中的皮层处理过程。
