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关于给予小鼠西式饮食6至24周后的食物、肝脏组织和线粒体脂肪酸组成以及线粒体蛋白质组变化的数据。

Data on chow, liver tissue and mitochondrial fatty acid compositions as well as mitochondrial proteome changes after feeding mice a western diet for 6-24 weeks.

作者信息

Einer Claudia, Hohenester Simon, Wimmer Ralf, Wottke Lena, Artmann Renate, Schulz Sabine, Gosmann Christian, Simmons Alisha, Leitzinger Christin, Eberhagen Carola, Borchard Sabine, Schmitt Sabine, Hauck Stefanie M, von Toerne Christine, Jastroch Martin, Walheim Ellen, Rust Christian, Gerbes Alexander L, Popper Bastian, Mayr Doris, Schnurr Max, Vollmar Angelika M, Denk Gerald, Zischka Hans

机构信息

Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany.

Department of Medicine II - Grosshadern, Liver Center Munich, LMU Munich, 81377 Munich, Germany.

出版信息

Data Brief. 2017 Sep 18;15:163-169. doi: 10.1016/j.dib.2017.09.019. eCollection 2017 Dec.

Abstract

The data presented in this article describe the fatty acid composition of chow, liver tissue and isolated liver mitochondria from mice fed for 6-24 weeks with a high caloric western diet (WD) in comparison to control diet (normal diet, ND). The fatty acid composition was measured via gas chromatography flame ionization detection (GC-FID). Moreover, WD-induced mitochondrial protein changes are presented in this work and were analyzed by mass spectrometry (LC-MS/MS). For further interpretation and discussion of the presented data please refer to the research article entitled "Mitochondrial adaptation in steatotic mice" (Einer et al., 2017) [1].

摘要

本文所呈现的数据描述了用高热量西式饮食(WD)喂养6 - 24周的小鼠的食物、肝脏组织及分离出的肝脏线粒体中的脂肪酸组成,并与对照饮食(正常饮食,ND)进行了比较。脂肪酸组成通过气相色谱火焰离子化检测(GC - FID)进行测定。此外,本研究展示了WD诱导的线粒体蛋白质变化,并通过质谱分析(LC - MS/MS)进行了分析。有关所呈现数据的进一步解读和讨论,请参考题为《脂肪变性小鼠的线粒体适应性》的研究文章(Einer等人,2017年)[1]。

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Mitochondrial adaptation in steatotic mice.肝脂肪变性小鼠的线粒体适应。
Mitochondrion. 2018 May;40:1-12. doi: 10.1016/j.mito.2017.08.015. Epub 2017 Sep 19.

引用本文的文献

本文引用的文献

1
Mitochondrial adaptation in steatotic mice.肝脂肪变性小鼠的线粒体适应。
Mitochondrion. 2018 May;40:1-12. doi: 10.1016/j.mito.2017.08.015. Epub 2017 Sep 19.
2
KEGG as a reference resource for gene and protein annotation.KEGG作为基因和蛋白质注释的参考资源。
Nucleic Acids Res. 2016 Jan 4;44(D1):D457-62. doi: 10.1093/nar/gkv1070. Epub 2015 Oct 17.
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UniProt: a hub for protein information.通用蛋白质数据库(UniProt):蛋白质信息中心。
Nucleic Acids Res. 2015 Jan;43(Database issue):D204-12. doi: 10.1093/nar/gku989. Epub 2014 Oct 27.
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Why to compare absolute numbers of mitochondria.为什么要比较线粒体的绝对数量。
Mitochondrion. 2014 Nov;19 Pt A:113-23. doi: 10.1016/j.mito.2014.06.005. Epub 2014 Jun 23.
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Universal sample preparation method for proteome analysis.蛋白质组分析的通用样本制备方法。
Nat Methods. 2009 May;6(5):359-62. doi: 10.1038/nmeth.1322. Epub 2009 Apr 19.

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