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富含AT序列结合蛋白2在小鼠磨牙发育以及人类健康牙齿和牙髓炎牙齿牙髓-牙本质复合体中的表达与定位

Expression and localization of special AT-rich sequence binding protein 2 in murine molar development and the pulp-dentin complex of human healthy teeth and teeth with pulpitis.

作者信息

He Lina, Liu Huimei, Shi Lei, Pan Shuang, Yang Xu, Zhang Lin, Niu Yumei

机构信息

Department of Endodontics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

出版信息

Exp Ther Med. 2017 Oct;14(4):3507-3512. doi: 10.3892/etm.2017.4980. Epub 2017 Aug 21.

DOI:10.3892/etm.2017.4980
PMID:29042940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5639343/
Abstract

Special AT-rich sequence binding protein 2 (SATB2) is a member of the special family of AT-rich binding transcription factors and has a critical role in osteoblast differentiation and craniofacial patterning. However, the expression and distribution of SATB2 in tooth development is largely unknown. The aim of the present study was to detect the expression and distribution of SATB2 during murine molar development and, in human healthy teeth and teeth with pulpitis using immunohistochemistry. Molars were obtained from Kunming mice at embryonic day (E) 13.5, E14.5, E16.5 and E18.5, and postnatal day (P) 1, P5 and P7. In addition, 20 human teeth (10 healthy and 10 teeth with pulpitis) were obtained from young adult patients (age, 24.90±1.65 years) who were scheduled for routine extraction. Immunohistochemical analyses were performed to detect the expression and distribution of SATB2. The present results revealed that SATB2 exhibits a spatiotemporal expression pattern in murine molar development and was expressed in odontoblasts, predentin, dental pulp cells and the blood vessels in human teeth. These findings suggested that SATB2 may have an important role in odontoblast differentiation and dentin matrix mineralization during tooth development.

摘要

富含AT序列的特殊结合蛋白2（SATB2）是富含AT结合转录因子特殊家族的成员，在成骨细胞分化和颅面模式形成中起关键作用。然而，SATB2在牙齿发育中的表达和分布情况在很大程度上尚不清楚。本研究的目的是利用免疫组织化学检测SATB2在小鼠磨牙发育过程中以及在人类健康牙齿和牙髓炎牙齿中的表达和分布。在胚胎第13.5天、14.5天、16.5天和18.5天以及出生后第1天、5天和7天从昆明小鼠获取磨牙。此外，从计划进行常规拔牙的年轻成年患者（年龄24.90±1.65岁）获取20颗人类牙齿（10颗健康牙齿和10颗牙髓炎牙齿）。进行免疫组织化学分析以检测SATB2的表达和分布。目前的结果显示，SATB2在小鼠磨牙发育中呈现时空表达模式，并且在人类牙齿的成牙本质细胞、前期牙本质、牙髓细胞和血管中表达。这些发现表明，SATB2在牙齿发育过程中的成牙本质细胞分化和牙本质基质矿化中可能起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bf0/5639343/ee5465e4538b/etm-14-04-3507-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bf0/5639343/5d819ca60bcb/etm-14-04-3507-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bf0/5639343/0a4507a7eaed/etm-14-04-3507-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bf0/5639343/837655f9b31a/etm-14-04-3507-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bf0/5639343/ee5465e4538b/etm-14-04-3507-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bf0/5639343/5d819ca60bcb/etm-14-04-3507-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bf0/5639343/0a4507a7eaed/etm-14-04-3507-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bf0/5639343/837655f9b31a/etm-14-04-3507-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bf0/5639343/ee5465e4538b/etm-14-04-3507-g03.jpg

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Expression and localization of special AT-rich sequence binding protein 2 in murine molar development and the pulp-dentin complex of human healthy teeth and teeth with pulpitis.

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引用本文的文献

[1]
Autism spectrum disorders and childhood caries: a comprehensive Mendelian randomization study.

BMC Pediatr. 2025-7-2

[2]
Region-specific gene expression profiling of early mouse mandible uncovered SATB2 as a key molecule for teeth patterning.

Sci Rep. 2024-8-6

[3]
The dental phenotype of primary dentition in SATB2-associated syndrome: a report of three cases and literature review.

BMC Oral Health. 2022-11-22

[4]
Involvement of the TNF-α/SATB2 axis in the induced apoptosis and inhibited autophagy of osteoblasts by the antipsychotic Risperidone.

Mol Med. 2022-5-3

[5]
A novel mutation of SATB2 inhibits odontogenesis of human dental pulp stem cells through Wnt/β-catenin signaling pathway.

Stem Cell Res Ther. 2021-12-4

[6]
Mutation update for the SATB2 gene.

Hum Mutat. 2019-6-18

[7]
Dental radiographic findings in 18 individuals with SATB2-associated syndrome.

Clin Oral Investig. 2018-11

本文引用的文献

[1]
Regulative Effect of Mir-205 on Osteogenic Differentiation of Bone Mesenchymal Stem Cells (BMSCs): Possible Role of SATB2/Runx2 and ERK/MAPK Pathway.

Int J Mol Sci. 2015-5-7

[2]
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J Endod. 2014-11

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Lentiviral-mediated expression of SATB2 promotes osteogenic differentiation of bone marrow stromal cells in vitro and in vivo.

Eur J Oral Sci. 2014-6

[4]
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Cytokine Growth Factor Rev. 2013-12-25

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SATB2 is a novel marker of osteoblastic differentiation and colorectal adenocarcinoma.

Adv Anat Pathol. 2014-1

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Contribution of SATB2 to the stronger osteogenic potential of bone marrow stromal cells from craniofacial bones.

Cell Tissue Res. 2012-9-7

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Binding of amelogenin to MMP-9 and their co-expression in developing mouse teeth.

J Mol Histol. 2012-5-31

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miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2.

J Cell Biol. 2012-5-7

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The expression pattern of FHL2 during mouse molar development.

J Mol Histol. 2012-3-30

[10]
Special AT-rich sequence-binding protein 2 and its related genes play key roles in the differentiation of MC3T3-E1 osteoblast like cells.

Biochem Biophys Res Commun. 2011-12-7

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