衰老和高血压中的动脉僵硬度：习惯性有氧运动的预防和治疗。
Aortic Stiffness in Aging and Hypertension: Prevention and Treatment with Habitual Aerobic Exercise.
机构信息
Department of Health and Human Physiology, University of Iowa, 225 S. Grand Ave, 412 FH, Iowa City, IA, 52242, USA.
UI Healthcare Center for Hypertension Research, University of Iowa, Iowa City, IA, 52242, USA.
出版信息
Curr Hypertens Rep. 2017 Oct 18;19(11):90. doi: 10.1007/s11906-017-0788-0.
PURPOSE OF REVIEW
Habitual aerobic exercise is associated with lower aortic stiffness, as measured by carotid-femoral pulse wave velocity (CFPWV), in middle-aged/older adults without hypertension, but beneficial effects of aerobic exercise on CFPWV in hypertension remain contraversial. Therefore, the focus of this review is to discuss the evidence for and against the beneficial effects of aerobic exercise on aortic stiffness in middle-aged and older adults with hypertension, possible limitations in these studies, and highlight novel directions for future research.
RECENT FINDINGS
Most randomized controlled intervention studies demonstrate that short-term aerobic exercise results in no reductions in CFPWV in middle-aged and/or older adults with treated or treatment-naïve hypertension. Higher aerobic fitness is not associated with lower aortic stiffness among older adults with treated hypertension. Aortic stiffness appears to be resistant to clinically relevant improvements in response to habitual aerobic exercise in the presence of hypertension among middle-aged and older adults.
目的综述
习惯性有氧运动与颈动脉-股动脉脉搏波速度（CFPWV）降低有关，可降低中年/老年高血压前期人群的主动脉僵硬度，但有氧运动对高血压患者 CFPWV 的有益作用仍存在争议。因此，本综述的重点是讨论有氧运动对中年和老年高血压患者主动脉僵硬度的有益作用的证据，以及这些研究的可能局限性，并强调未来研究的新方向。
最近的发现
大多数随机对照干预研究表明，短期有氧运动并不能降低治疗或未经治疗的高血压中年和/或老年患者的 CFPWV。在接受治疗的高血压老年患者中，较高的有氧运动能力与较低的主动脉僵硬度无关。在中年和老年高血压患者中，主动脉僵硬度似乎对习惯性有氧运动引起的临床相关改善具有抗性。
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