Dighe R, Vaidya V G
Department of Zoology, M.A.C.S. Research Institute, Pune, India.
Teratog Carcinog Mutagen. 1988;8(3):169-74. doi: 10.1002/tcm.1770080306.
Five ergot alkaloids, d-lysergic acid derivatives, were tested for the induction of sister chromatid exchange (SCE) frequencies in cultured Chinese hamster ovary cells. The concentrations of the test substances ranged between 10(-5) and 10(-8) M. Ergotamine, ergonovine, and methylergonovine induced a significantly high number of SCEs at all the concentrations used, while with ergocristine this occurred only at the highest concentration. alpha-Ergocryptine failed to induce SCEs at any concentration. It is therefore surmised that ergotamine, ergonovine, and methylergonovine are effective inducers, ergocristine is a weak inducer, and alpha-ergocryptine is a noninducer in Chinese hamster ovary cells in vitro.
测试了5种麦角生物碱，即d - 麦角酸衍生物，以诱导培养的中国仓鼠卵巢细胞中的姐妹染色单体交换（SCE）频率。测试物质的浓度范围为10(-5)至10(-8) M。麦角胺、麦角新碱和甲基麦角新碱在所有使用的浓度下均诱导出显著高数量的SCE，而麦角克碱仅在最高浓度下才出现这种情况。α-麦角隐亭在任何浓度下均未诱导出SCE。因此推测，在体外培养的中国仓鼠卵巢细胞中，麦角胺、麦角新碱和甲基麦角新碱是有效的诱导剂，麦角克碱是弱诱导剂，而α-麦角隐亭是无诱导作用的物质。
