• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

发育温度是否通过过氧化物酶的上调影响线虫的氧化还原水平和寿命?

Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin?

机构信息

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.

出版信息

Redox Biol. 2018 Apr;14:386-390. doi: 10.1016/j.redox.2017.10.003. Epub 2017 Oct 7.

DOI:10.1016/j.redox.2017.10.003
PMID:29055282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5647470/
Abstract

Lifespan in poikilothermic organisms, such as Caenorhabditis elegans, can be substantially increased simply by decreasing growth temperature. To gain insights into the mechanistic underpinnings of this effect, we investigated the effects of temperature in development and adulthood on C. elegans lifespan. We found that worms exposed to 25°C during development and shifted to 15°C in adulthood exhibited an even longer lifespan than animals constantly kept at 15°C. Analysis of the in vivo redox status demonstrated that at 25°C, C. elegans larvae have a more reduced redox state and higher Prdx-2 expression levels than animals raised at 15°C. Worms lacking prdx-2 fail to show the additional lifespan extension upon shift from 25°C to 15°C and reveal a lifespan similar to prdx-2 worms always kept at 15°C. These results suggest that transiently altering the in vivo redox state during development can have highly beneficial long-term consequences for organisms.

摘要

在变温动物(如秀丽隐杆线虫)中,仅仅通过降低生长温度就可以显著延长其寿命。为了深入了解这种效应的机制基础,我们研究了温度在发育和成年期对秀丽隐杆线虫寿命的影响。我们发现,在发育过程中暴露于 25°C 并在成年后转移到 15°C 的线虫比始终保持在 15°C 的动物寿命更长。体内氧化还原状态的分析表明,在 25°C 下,秀丽隐杆线虫幼虫的氧化还原状态更还原,Prdx-2 表达水平更高,而在 15°C 下培养的动物则不然。缺乏 prdx-2 的线虫在从 25°C 转移到 15°C 时不会表现出额外的寿命延长,并且其寿命与始终保持在 15°C 的 prdx-2 线虫相似。这些结果表明,在发育过程中短暂改变体内氧化还原状态可能对生物体产生非常有益的长期影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c92/5647470/bf7ca2d2c299/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c92/5647470/4bae9df7ed0c/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c92/5647470/3c8978e72c63/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c92/5647470/6e3ef8cf5791/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c92/5647470/d3c6bbcb2cc0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c92/5647470/bf7ca2d2c299/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c92/5647470/4bae9df7ed0c/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c92/5647470/3c8978e72c63/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c92/5647470/6e3ef8cf5791/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c92/5647470/d3c6bbcb2cc0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c92/5647470/bf7ca2d2c299/gr4.jpg

相似文献

1
Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin?发育温度是否通过过氧化物酶的上调影响线虫的氧化还原水平和寿命?
Redox Biol. 2018 Apr;14:386-390. doi: 10.1016/j.redox.2017.10.003. Epub 2017 Oct 7.
2
A peroxiredoxin, PRDX-2, is required for insulin secretion and insulin/IIS-dependent regulation of stress resistance and longevity.一种过氧化物还原酶PRDX-2是胰岛素分泌以及胰岛素/胰岛素/胰岛素样生长因子信号通路依赖性应激抗性和寿命调节所必需的。
Aging Cell. 2015 Aug;14(4):558-68. doi: 10.1111/acel.12321. Epub 2015 Mar 23.
3
Is overoxidation of peroxiredoxin physiologically significant?过氧化物还原酶的过度氧化在生理上是否有意义?
Antioxid Redox Signal. 2011 Feb 15;14(4):725-30. doi: 10.1089/ars.2010.3717. Epub 2010 Dec 17.
4
A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.一种对寿命很重要的氧化还原敏感型过氧化物酶在抗逆性中具有组织和应激特异性作用。
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19839-44. doi: 10.1073/pnas.0805507105. Epub 2008 Dec 8.
5
Peroxiredoxin 2 is required for the redox mediated adaptation to exercise.过氧化物酶 2 是氧化还原介导的运动适应所必需的。
Redox Biol. 2023 Apr;60:102631. doi: 10.1016/j.redox.2023.102631. Epub 2023 Feb 9.
6
Larval crowding accelerates C. elegans development and reduces lifespan.幼虫拥挤会加速秀丽隐杆线虫的发育并缩短其寿命。
PLoS Genet. 2017 Apr 10;13(4):e1006717. doi: 10.1371/journal.pgen.1006717. eCollection 2017 Apr.
7
Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing.过氧化物酶 2 调节 DAF-16/FOXO 介导的线粒体重塑以响应运动,而这种运动在衰老中被打乱。
Mol Metab. 2024 Oct;88:102003. doi: 10.1016/j.molmet.2024.102003. Epub 2024 Aug 6.
8
Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans.秀丽隐杆线虫中长寿的isp-1线粒体突变体的氧化应激抗性与寿命的解偶联。
Free Radic Biol Med. 2017 Jul;108:362-373. doi: 10.1016/j.freeradbiomed.2017.04.004. Epub 2017 Apr 7.
9
Loss of miR-83 extends lifespan and affects target gene expression in an age-dependent manner in Caenorhabditis elegans.miR-83 的缺失以依赖年龄的方式延长秀丽隐杆线虫的寿命并影响靶基因的表达。
J Genet Genomics. 2018 Dec 20;45(12):651-662. doi: 10.1016/j.jgg.2018.11.003. Epub 2018 Dec 9.
10
Piceatannol extends the lifespan of Caenorhabditis elegans via DAF-16.白皮杉醇通过DAF-16延长秀丽隐杆线虫的寿命。
Biofactors. 2017 May 6;43(3):379-387. doi: 10.1002/biof.1346. Epub 2017 Jan 27.

引用本文的文献

1
Peroxiredoxin 2 is required for the redox mediated adaptation to exercise.过氧化物酶 2 是氧化还原介导的运动适应所必需的。
Redox Biol. 2023 Apr;60:102631. doi: 10.1016/j.redox.2023.102631. Epub 2023 Feb 9.
2
Metabolism, homeostasis, and aging.代谢、内稳态和衰老。
Trends Endocrinol Metab. 2023 Mar;34(3):158-169. doi: 10.1016/j.tem.2023.01.003. Epub 2023 Jan 20.
3
Typical 2-Cys Peroxiredoxins as a Defense Mechanism against Metal-Induced Oxidative Stress in the Solitary Ascidian .典型的2-半胱氨酸过氧化物酶作为单海鞘中抵御金属诱导氧化应激的防御机制

本文引用的文献

1
How and why pH changes with body temperature: the α-stat hypothesis.pH如何以及为何随体温变化:α-稳态假说。
J Exp Biol. 2016 Apr 15;219(Pt 8):1090-2. doi: 10.1242/jeb.139220.
2
HyPer Family Probes: State of the Art.HyPer家族探针:最新技术水平
Antioxid Redox Signal. 2016 May 1;24(13):731-51. doi: 10.1089/ars.2015.6586. Epub 2016 Jan 11.
3
Environmental Temperature Differentially Modulates C. elegans Longevity through a Thermosensitive TRP Channel.环境温度通过一个热敏性瞬时受体电位(TRP)通道差异性地调节秀丽隐杆线虫的寿命。
Antioxidants (Basel). 2021 Dec 30;11(1):93. doi: 10.3390/antiox11010093.
4
In Vivo Imaging with Genetically Encoded Redox Biosensors.体内成像用基因编码氧化还原生物传感器。
Int J Mol Sci. 2020 Oct 31;21(21):8164. doi: 10.3390/ijms21218164.
5
TrxR2 overexpression alleviates inflammation-mediated neuronal death reducing the oxidative stress and activating the Akt-Parkin pathway.硫氧还蛋白还原酶2(TrxR2)过表达通过降低氧化应激和激活Akt-帕金通路减轻炎症介导的神经元死亡。
Toxicol Res (Camb). 2019 Jun 11;8(5):641-653. doi: 10.1039/c9tx00076c. eCollection 2019 Sep 1.
6
Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: A novel mechanism linking Ripk3-modified mitochondrial performance and endoplasmic reticulum function.褪黑素对脓毒症性心肌病治疗作用的研究进展:一个联系 Ripk3 修饰的线粒体功能和内质网功能的新机制。
Redox Biol. 2019 Sep;26:101287. doi: 10.1016/j.redox.2019.101287. Epub 2019 Jul 27.
7
The glutathione system and the related thiol network in Caenorhabditis elegans.秀丽隐杆线虫中的谷胱甘肽系统和相关硫醇网络。
Redox Biol. 2019 Jun;24:101171. doi: 10.1016/j.redox.2019.101171. Epub 2019 Mar 16.
8
Genetic ablation of TAZ induces HepG2 liver cancer cell apoptosis through activating the CaMKII/MIEF1 signaling pathway.TAZ的基因消融通过激活CaMKII/MIEF1信号通路诱导肝癌HepG2细胞凋亡。
Onco Targets Ther. 2019 Mar 1;12:1765-1779. doi: 10.2147/OTT.S196142. eCollection 2019.
9
Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging.细胞质和线粒体 NADPH 偶联的氧化还原系统在衰老调控中的作用。
Nutrients. 2019 Feb 27;11(3):504. doi: 10.3390/nu11030504.
Cell Rep. 2015 Jun 9;11(9):1414-24. doi: 10.1016/j.celrep.2015.04.066. Epub 2015 May 28.
4
The free radical theory of aging revisited: the cell signaling disruption theory of aging.重新审视衰老的自由基理论:衰老的细胞信号中断理论。
Antioxid Redox Signal. 2013 Sep 10;19(8):779-87. doi: 10.1089/ars.2012.5111.
5
Quantitative in vivo redox sensors uncover oxidative stress as an early event in life.定量活体氧化还原传感器揭示氧化应激是生命早期的一个事件。
Mol Cell. 2012 Sep 14;47(5):767-76. doi: 10.1016/j.molcel.2012.06.016. Epub 2012 Jul 19.
6
Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans.探索发育中和衰老中的秀丽隐杆线虫实时体内氧化还原生物学。
Free Radic Biol Med. 2012 Mar 1;52(5):850-9. doi: 10.1016/j.freeradbiomed.2011.11.037. Epub 2011 Dec 23.
7
FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1.氟尿苷导致线粒体突变体 gas-1 的寿命延长了两倍。
Mech Ageing Dev. 2011 Oct;132(10):519-21. doi: 10.1016/j.mad.2011.08.006. Epub 2011 Aug 27.
8
Effects of oxidative stress on behavior, physiology, and the redox thiol proteome of Caenorhabditis elegans.氧化应激对秀丽隐杆线虫行为、生理和氧化还原硫醇蛋白质组的影响。
Antioxid Redox Signal. 2011 Mar 15;14(6):1023-37. doi: 10.1089/ars.2010.3203. Epub 2010 Oct 28.
9
A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.一种对寿命很重要的氧化还原敏感型过氧化物酶在抗逆性中具有组织和应激特异性作用。
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19839-44. doi: 10.1073/pnas.0805507105. Epub 2008 Dec 8.
10
Real-time imaging of the intracellular glutathione redox potential.细胞内谷胱甘肽氧化还原电位的实时成像
Nat Methods. 2008 Jun;5(6):553-9. doi: 10.1038/nmeth.1212. Epub 2008 May 11.