CaMKII blockade, cardiac conduction, and arrhythmia.
作者信息
Warren Mark, Zaitsev Alexey V
机构信息
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, USA.
出版信息
Cardiovasc Res. 2017 Dec 1;113(14):1798-1799. doi: 10.1093/cvr/cvx199.
Abstract
摘要
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CaMKII blockade, cardiac conduction, and arrhythmia.钙调蛋白激酶II阻断、心脏传导与心律失常
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本文引用的文献
1
Blockade of CaMKII depresses conduction preferentially in the right ventricular outflow tract and promotes ischemic ventricular fibrillation in the rabbit heart.抑制CaMKII会优先抑制家兔心脏右心室流出道的传导，并促进缺血性心室颤动。
Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H752-H767. doi: 10.1152/ajpheart.00347.2016. Epub 2017 Jan 27.
2
Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent.钙调蛋白/钙调蛋白依赖性蛋白激酶II抑制可改善心脏中的细胞间通讯和冲动传导，并且在无纤维化的情况下具有抗心律失常作用。
Cardiovasc Res. 2016 Sep;111(4):410-21. doi: 10.1093/cvr/cvw173. Epub 2016 Jun 29.
3
KN-93 inhibits IKr in mammalian cardiomyocytes.KN-93抑制哺乳动物心肌细胞中的IKr。
J Mol Cell Cardiol. 2015 Dec;89(Pt B):173-6. doi: 10.1016/j.yjmcc.2015.10.012. Epub 2015 Oct 14.
4
CaMKII inhibitors: from research tools to therapeutic agents.钙调蛋白激酶II抑制剂：从研究工具到治疗药物。
Front Pharmacol. 2014 Feb 20;5:21. doi: 10.3389/fphar.2014.00021. eCollection 2014.
5
Calmodulin binding proteins provide domains of local Ca2+ signaling in cardiac myocytes.钙调蛋白结合蛋白在心肌细胞中提供局部 Ca2+信号的结构域。
J Mol Cell Cardiol. 2012 Feb;52(2):312-6. doi: 10.1016/j.yjmcc.2011.06.005. Epub 2011 Jun 12.
6
The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide directly blocks human ether à-go-go-related gene potassium channels stably expressed in human embryonic kidney 293 cells.钙调蛋白抑制剂 N-(6-氨基己基)-5-氯-1-萘磺酰胺直接阻断稳定表达于人肾 293 细胞的人 ether à-go-go 相关基因钾通道。
Br J Pharmacol. 2010 Oct;161(4):872-84. doi: 10.1111/j.1476-5381.2010.00916.x.
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Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes.豚鼠心室肌细胞中Ca2+/钙调蛋白和Ca2+/钙调蛋白依赖性蛋白激酶II对Na+通道的调节
Cardiovasc Res. 2010 Feb 1;85(3):454-63. doi: 10.1093/cvr/cvp324. Epub 2009 Oct 1.
8
Constitutive CaMKII activity regulates Na+ channel in rat ventricular myocytes.组成型钙/钙调蛋白依赖性蛋白激酶II活性调节大鼠心室肌细胞中的钠通道。
J Mol Cell Cardiol. 2009 Oct;47(4):475-84. doi: 10.1016/j.yjmcc.2009.06.020. Epub 2009 Jul 8.
9
W-7 modulates Kv4.3: pore block and Ca2+-calmodulin inhibition.W-7调节Kv4.3：孔道阻断和钙调蛋白抑制。
Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2364-77. doi: 10.1152/ajpheart.00409.2005. Epub 2007 Jan 12.
10
Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels.钙调蛋白依赖性蛋白激酶II调节心脏钠离子通道。
J Clin Invest. 2006 Dec;116(12):3127-38. doi: 10.1172/JCI26620. Epub 2006 Nov 22.
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