Cancer Immunology, Department of Translational Medicine, Lund University, Malmö, Sweden.
Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden.
Cancer Biomark. 2017 Dec 8;20(4):395-409. doi: 10.3233/CBM-170026.
Tumor-infiltrating lymphocytes (TILs) have a strong prognostic value in various forms of cancers. These data often refer to use of the pan-T cell marker CD3, or the cytotoxic T lymphocyte marker CD8α. However, T cells are a heterogeneous group of cells with a wide array of effector mechanisms ranging from immunosuppression to cytotoxicity.
In this study we have investigated the prognostic effects of some unconventional T cell subtypes in breast cancer; γδ T cells, IL-17+ T cells and FoxP3+ T cells (Tregs) in relation to the conventional CD3 and CD8α T cell markers.
This was done using immunohistochemistry on a human breast cancer tissue microarray consisting of 498 consecutive cases of primary breast cancer.
Infiltration of γδ T cells and T cell infiltration in general (CD3), correlated with a good prognosis, while Treg infiltration with a worse. Infiltration of γδ T cells was associated with a significantly improved clinical outcome in all breast cancer subtypes except triple negative tumors. Only infiltration of either CD3+ or CD8α+ cells was independently associated with better prognosis for all breast cancer patients.
This study sheds further light on the prognostic impact of various T cell subtypes in breast cancer.
肿瘤浸润淋巴细胞（TILs）在各种癌症中具有很强的预后价值。这些数据通常是指使用泛 T 细胞标志物 CD3 或细胞毒性 T 淋巴细胞标志物 CD8α。然而，T 细胞是一组具有广泛效应机制的异质性细胞群，从免疫抑制到细胞毒性不等。
在这项研究中，我们研究了乳腺癌中一些非常规 T 细胞亚群的预后影响；γδ T 细胞、IL-17+T 细胞和 FoxP3+T 细胞（Tregs）与常规 CD3 和 CD8α T 细胞标志物的关系。
这是通过对由 498 例连续原发性乳腺癌组成的人类乳腺癌组织微阵列进行免疫组织化学来完成的。
γδ T 细胞和 T 细胞浸润（CD3）与预后较好相关，而 Treg 浸润则与预后较差相关。γδ T 细胞浸润与所有乳腺癌亚型（除三阴性肿瘤外）的临床结局显著改善相关。只有 CD3+或 CD8α+细胞的浸润与所有乳腺癌患者的更好预后独立相关。
这项研究进一步阐明了各种 T 细胞亚群在乳腺癌中的预后影响。
