Rensburg Megan A, Matsha Tandi, Hoffmann Mariza, Hassan Mogamat S, Erasmus Rajiv T
Division of Chemical Pathology, National Health Laboratory Service, Tygerberg Hospital, Stellenbosch University, South Africa.
Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, South Africa.
Afr J Lab Med. 2012 Jun 4;1(1):10. doi: 10.4102/ajlm.v1i1.10. eCollection 2012.
Metabolic syndrome (MetS) and its associated cardiovascular risk are on the increase in children. High-sensitivity C-reactive protein (hs-CRP) has emerged as a useful marker for inflammation associated with atherosclerosis and cardiovascular disease. Our aim was to determine the distribution of hs-CRP in an effort to identify the MetS variable that is critical in modulating plasma CRP levels in a population of South African adolescents.
A cross-sectional analytical study design was used for this investigation, where the dependent and independent variables were measured simultaneously.
Anthropometric variables, blood pressure, fasting blood glucose and lipids were performed on 324 consenting learners aged 15-18 years from three different ethnic groups (Black, White and Coloured). The National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) for ages 15-18 year olds was used to define MetS.
The prevalence of MetS and obesity was 3.7% and 7.1%, respectively. The hs-CRP levels were significantly higher in subjects with a waist-circumference greater than the 90th percentile ( < 0.01) and in obese learners with MetS, but was lower in adolescents with normal weight and MetS. Median hs-CRP levels increased with an increasing number of metabolic abnormalities and exceeded 3 mg/L in 19% of adolescents. Gender and ethnic differences were observed.
Our findings suggest that obesity and waist circumference appear to be major mediators of hs-CRP levels in South African adolescents.
代谢综合征（MetS）及其相关的心血管风险在儿童中呈上升趋势。高敏C反应蛋白（hs-CRP）已成为与动脉粥样硬化和心血管疾病相关炎症的有用标志物。我们的目的是确定hs-CRP的分布情况，以识别在调节南非青少年人群血浆CRP水平中起关键作用的MetS变量。
本研究采用横断面分析研究设计，同时测量自变量和因变量。
对来自三个不同种族（黑人、白人和混血）的324名年龄在15 - 18岁的同意参与研究的学生进行人体测量变量、血压、空腹血糖和血脂检测。使用针对15 - 18岁人群的美国国家胆固醇教育计划成人治疗小组第三次报告（NCEP ATP III）来定义MetS。
MetS和肥胖的患病率分别为3.7%和7.1%。腰围大于第90百分位数的受试者（<0.01）以及患有MetS的肥胖学生的hs-CRP水平显著更高，但体重正常且患有MetS的青少年的hs-CRP水平较低。hs-CRP中位数水平随着代谢异常数量的增加而升高，19%的青少年超过3mg/L。观察到了性别和种族差异。
我们的研究结果表明，肥胖和腰围似乎是南非青少年hs-CRP水平的主要调节因素。
