高乳制品蛋白摄入与老年男性桡骨远端和胫骨的骨强度参数增加有关：一项横断面研究。
High dairy protein intake is associated with greater bone strength parameters at the distal radius and tibia in older men: a cross-sectional study.
机构信息
Division of Epidemiology and Community Health, University of Minnesota, 1300 S. 2nd St., Suite 300, Minneapolis, MN, 55454, USA.
Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
出版信息
Osteoporos Int. 2018 Jan;29(1):69-77. doi: 10.1007/s00198-017-4261-3. Epub 2017 Oct 23.
UNLABELLED
Dairy protein but not plant protein was associated with bone strength of the radius and tibia in older men. These results are consistent with previous results in women and support similar findings related to fracture outcomes. Bone strength differences were largely due to thickness and area of the bone cortex.
INTRODUCTION
Our objective was to determine the association of protein intake by source (dairy, non-dairy animal, plant) with bone strength and bone microarchitecture among older men.
METHODS
We used data from 1016 men (mean 84.3 years) who attended the Year 14 exam of the Osteoporotic Fractures in Men (MrOS) study, completed a food frequency questionnaire (500-5000 kcal/day), were not taking androgen or androgen agonists, and had high-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the distal radius and distal or diaphyseal tibia. Protein was expressed as percentage of total energy intake (TEI); mean ± SD for TEI = 1548 ± 607 kcal/day and for total protein = 16.2 ± 2.9%TEI. We used linear regression with standardized HR-pQCT parameters as dependent variables and adjusted for age, limb length, center, education, race/ethnicity, marital status, smoking, alcohol intake, physical activity level, corticosteroids use, supplement use (calcium and vitamin D), and osteoporosis medications.
RESULTS
Higher dairy protein intake was associated with higher estimated failure load at the distal radius and distal tibia [radius effect size = 0.17 (95% CI 0.07, 0.27), tibia effect size = 0.13 (95% CI 0.03, 0.23)], while higher non-dairy animal protein was associated with higher failure load at only the distal radius. Plant protein intake was not associated with failure load at any site.
CONCLUSION
The association between protein intake and bone strength varied by source of protein. These results support a link between dairy protein intake and skeletal health, but an intervention study is needed to evaluate causality.
未加标签
乳制品蛋白而非植物蛋白与老年人桡骨和胫骨的骨强度相关。这些结果与女性的先前结果一致，并支持与骨折结果相关的类似发现。骨强度差异主要归因于骨皮质的厚度和面积。
引言
我们的目的是确定蛋白质的摄入来源（乳制品、非乳制品动物、植物）与老年男性骨强度和骨微结构的关系。
方法
我们使用了 1016 名男性（平均年龄 84.3 岁）的数据，这些男性参加了男性骨质疏松性骨折研究（MrOS）的第 14 年检查，完成了食物频率问卷（500-5000kcal/天），未服用雄激素或雄激素激动剂，并且进行了高分辨率外周定量计算机断层扫描（HR-pQCT）检查桡骨远端和远端或骨干胫骨。蛋白质以总能量摄入（TEI）的百分比表示；TEI 的平均值±标准差为 1548±607kcal/天，总蛋白为 16.2±2.9%TEI。我们使用线性回归，将 HR-pQCT 的标准化参数作为因变量，并根据年龄、肢体长度、中心、教育程度、种族/民族、婚姻状况、吸烟、饮酒量、体力活动水平、皮质类固醇使用、补充剂使用（钙和维生素 D）以及骨质疏松症药物进行了调整。
结果
较高的乳制品蛋白摄入与桡骨远端和胫骨远端的估计失效负荷较高相关[桡骨效应大小=0.17（95%置信区间 0.07，0.27），胫骨效应大小=0.13（95%置信区间 0.03，0.23）]，而较高的非乳制品动物蛋白摄入仅与桡骨远端的失效负荷较高相关。植物蛋白摄入与任何部位的失效负荷均无关。
结论
蛋白质摄入与骨强度之间的关联因蛋白质的来源而异。这些结果支持乳制品蛋白摄入与骨骼健康之间的联系，但需要进行干预研究以评估因果关系。
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