Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC, USA.
Department of Medicine, Duke University Medical Center, Durham, NC, USA.
J Nutr Gerontol Geriatr. 2021 Apr-Jun;40(2-3):150-170. doi: 10.1080/21551197.2021.1896615. Epub 2021 Mar 13.
In contrast to recommendations for young and middle-aged adults, intentional weight loss among older adults remains controversial and is inconsistently advised. Recent research suggests that a higher protein diet can mitigate loss of lean mass during periods of intentional weight loss among older adults with obesity; however, the effects of intentional weight loss on skeletal muscle and bone are not fully understood. The (DDYNAMO) trial is a 6-month, randomized, controlled pilot study assessing the effects of combining regular, generous intakes of high quality protein (30 g/meal; primarily from dairy) with caloric restriction (-500kcal/d) and low-intensity resistance exercise (30 min/3 times per week) on muscle quality, muscle composition, bone mineral density in men and women aged ≥60 years with obesity and mild to moderate functional impairment (Short Physical Performance Battery [SPPB] score ≥4 to ≤10). Participants will be re-assessed at 18 months to evaluate weight maintenance, bone mineral density, physical function, and other secondary measures. NCT02437643.
与推荐年轻人和中年人减肥不同，老年人减肥仍然存在争议，且建议并不一致。最近的研究表明，高蛋白饮食可以减轻肥胖老年人在减肥期间瘦体重的损失；然而，减肥对骨骼肌和骨骼的影响尚未完全了解。DDYNAMO 试验是一项为期 6 个月的随机对照初步研究，旨在评估定期、大量摄入高质量蛋白质（每餐 30 克；主要来自乳制品）与热量限制（每天减少 500 千卡）和低强度阻力运动（每周 3 次，每次 30 分钟）相结合对肌肉质量、肌肉成分和骨矿物质密度的影响，研究对象为年龄≥60 岁且有肥胖和轻至中度功能障碍（短体适能表现电池测试 [SPPB]评分≥4 分至≤10 分）的男性和女性。参与者将在 18 个月时再次接受评估，以评估体重维持、骨矿物质密度、身体功能和其他次要指标。NCT02437643。
