Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Institute of Pathology, University of Belgrade, Belgrade, 11,000, Serbia.
Curr Hypertens Rep. 2017 Oct 23;19(11):93. doi: 10.1007/s11906-017-0786-2.
The aim of the study is to perform a critical assessment of in vitro models of pre-eclampsia using complementary human and cell line-based studies. Molecular mechanisms involved in spiral uterine artery (SUA) remodelling and trophoblast functionality will also be discussed.
A number of proteins and microRNAs have been implicated as key in SUA remodelling, which could be explored as early biomarkers or therapeutic targets for prevention of pre-eclampsia. Various 2D and 3D in vitro models involving trophoblast cells, endothelial cells, immune cells and placental tissue were discussed to elucidate the pathogenesis of pre-eclampsia. Nevertheless, pre-eclampsia is a multifactorial disease, and the mechanisms involved in its pathogenesis are complex and still largely unknown. Further studies are required to provide better understanding of the key processes leading to inappropriate placental development which is the root cause of pre-eclampsia. This new knowledge could identify novel biomarkers and treatment strategies.
本研究旨在通过补充的基于人和细胞系的研究，对先兆子痫的体外模型进行批判性评估。还将讨论涉及螺旋子宫动脉（SUA）重塑和滋养层功能的分子机制。
一些蛋白质和 microRNAs 被认为是 SUA 重塑的关键，它们可以作为先兆子痫预防的早期生物标志物或治疗靶点进行探索。讨论了各种涉及滋养层细胞、内皮细胞、免疫细胞和胎盘组织的 2D 和 3D 体外模型，以阐明先兆子痫的发病机制。然而，先兆子痫是一种多因素疾病，其发病机制涉及的机制复杂且仍在很大程度上未知。需要进一步的研究来更好地了解导致胎盘发育异常的关键过程，这是先兆子痫的根本原因。这些新知识可以确定新的生物标志物和治疗策略。
