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从广藿香内生真菌埃氏炭团菌(Daldinia eschscholtzii)中分离出的两种新代谢产物。

Two new metabolites from Daldinia eschscholtzii, an endophytic fungus derived from Pogostemon cablin.

作者信息

Liu Hong-Xin, Tan Hai-Bo, Li Sai-Ni, Chen Yu-Chan, Li Hao-Hua, Zhang Wei-Min

机构信息

a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou 510070 , China.

b Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou 510650 , China.

出版信息

J Asian Nat Prod Res. 2019 Feb;21(2):150-156. doi: 10.1080/10286020.2017.1392512. Epub 2017 Oct 24.

DOI:10.1080/10286020.2017.1392512
PMID:29063789
Abstract

The chemical investigation of the mycelia of endophytic fungus Daldinia eschscholtzii A630, which was isolated from the medicinal plant Pogostemon cablin, resulted in the isolation of two new compounds, named eschscholin A (1), 3-ene-2-methyl-2H-1-benzopyran-5-ol (2), and one new natural product 3,5-dihydroxy-2-methyl-4H-chromen-4-one (3), along with seven known compounds. Their structures were fully characterized by means of detailed spectroscopic analysis, and in comparison with published data for known compounds. All of the isolated compounds (1-10) were evaluated for their antibacterial activities.

摘要

对从药用植物广藿香中分离出的内生真菌埃氏炭团菌A630的菌丝体进行化学研究,从中分离出两种新化合物,分别命名为埃氏菌素A(1)、3-烯-2-甲基-2H-1-苯并吡喃-5-醇(2),以及一种新的天然产物3,5-二羟基-2-甲基-4H-色原酮(3),同时还分离出七种已知化合物。通过详细的光谱分析并与已知化合物的已发表数据进行比较,对它们的结构进行了全面表征。对所有分离出的化合物(1-10)进行了抗菌活性评估。

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