Stewart Exposure Assessments, LLC, Arlington, Virginia, USA.
Exposure Assessment Applications, LLC, Arlington, Virginia, USA.
J Expo Sci Environ Epidemiol. 2018 May;28(3):223-230. doi: 10.1038/jes.2017.16. Epub 2017 Oct 18.
The GuLF STUDY is a cohort study investigating the health of workers who responded to the Deepwater Horizon oil spill in the Gulf of Mexico in 2010. The objective of this effort was to develop an ordinal job-exposure matrix (JEM) of airborne total hydrocarbons (THC), dispersants, and particulates to estimate study participants' exposures. Information was collected on participants' spill-related tasks. A JEM of exposure groups (EGs) was developed from tasks and THC air measurements taken during and after the spill using relevant exposure determinants. THC arithmetic means were developed for the EGs, assigned ordinal values, and linked to the participants using determinants from the questionnaire. Different approaches were taken for combining exposures across EGs. EGs for dispersants and particulates were based on questionnaire responses. Considerable differences in THC exposure levels were found among EGs. Based on the maximum THC level participants experienced across any job held, ∼14% of the subjects were identified in the highest exposure category. Approximately 10% of the cohort was exposed to dispersants or particulates. Considerable exposure differences were found across the various EGs, facilitating investigation of exposure-response relationships. The JEM is flexible to allow for different assumptions about several possibly relevant exposure metrics.
海湾劳工健康研究是一项队列研究,调查了 2010 年在墨西哥湾应对深海地平线石油泄漏事件的工人的健康状况。这项研究的目的是开发一个基于任务的空气总碳氢化合物(THC)、分散剂和颗粒物的有序职业暴露矩阵(JEM),以估计研究参与者的暴露情况。收集了有关参与者与溢油相关任务的信息。根据溢油期间和之后的任务和 THC 空气测量值,使用相关的暴露决定因素,开发了暴露组(EG)的 JEM。为 EG 开发了 THC 算术平均值,分配了有序值,并使用问卷中的决定因素将其与参与者联系起来。采用了不同的方法来组合 EG 之间的暴露。分散剂和颗粒物的 EG 基于问卷回答。在 EG 之间发现了相当大的 THC 暴露水平差异。根据参与者在任何工作中经历的最大 THC 水平,约 14%的受试者被归入最高暴露类别。大约 10%的队列接触到了分散剂或颗粒物。在各种 EG 之间发现了相当大的暴露差异,这有利于研究暴露-反应关系。JEM 具有灵活性,可以对几个可能相关的暴露指标做出不同的假设。